Journal:Acta Cryst D:S2059798319006995
From Proteopedia
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The binding epitopes of antibodies could contribute to understand their anti-tumor activities. Our HuA21-HER2 structure clearly shows that the epitope of HuA21 is located at the C-terminal part of subdomain I of HER2. This is a new epitope distinct from those described for Trastuzumab and Pertuzumab, which are located at subdomains IV and II, respectively. | The binding epitopes of antibodies could contribute to understand their anti-tumor activities. Our HuA21-HER2 structure clearly shows that the epitope of HuA21 is located at the C-terminal part of subdomain I of HER2. This is a new epitope distinct from those described for Trastuzumab and Pertuzumab, which are located at subdomains IV and II, respectively. | ||
| - | <scene name='81/816443/Cv/3'>Overall structure of HuA21 scFv in complex with HER2 ECD</scene>. In ECD, the subdomains I, II, III and IV are colored red, green, blue and yellow, respectively. The light chain (V<sub>L</sub>) and heavy chain (V<sub>H</sub>) of HuA21 scFv are colored magenta and cyan, respectively. | + | <scene name='81/816443/Cv/3'>Overall structure of HuA21 scFv in complex with HER2 ECD</scene>. In ECD, the subdomains I, II, III and IV are colored red, green, blue and yellow, respectively. The light chain (V<sub>L</sub>) and heavy chain (V<sub>H</sub>) of HuA21 scFv are colored magenta and cyan, respectively. <scene name='81/816443/Cv/4'>HuA21 consists of two immunoglobulin domains formed by the VH and VL fragments</scene>, respectively. <scene name='81/816443/Cv/5'>The extracellular domain of HER2 is composed of four subdomains designated I, II, III and IV</scene>. |
<b>References</b><br> | <b>References</b><br> | ||
Revision as of 11:33, 23 May 2019
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This page complements a publication in scientific journals and is one of the Proteopedia's Interactive 3D Complement pages. For aditional details please see I3DC.
