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Cytochrome P450
From Proteopedia
(Difference between revisions)
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<StructureSection load='' size='350' side='right' caption='Cytochrome P450 CypC2 with heme C complex with warfarin (PDB entry [[1og5]])' scene='43/430105/Cv/2'> | <StructureSection load='' size='350' side='right' caption='Cytochrome P450 CypC2 with heme C complex with warfarin (PDB entry [[1og5]])' scene='43/430105/Cv/2'> | ||
| + | __TOC__ | ||
| + | == Function == | ||
[[Cytochrome P450]] (P450) catalyzes the oxidation of organic substances like lipids. The P450 contains a heme cofactor. The protein is numbered by its gene.<ref>PMID:12369887</ref>.<br /> | [[Cytochrome P450]] (P450) catalyzes the oxidation of organic substances like lipids. The P450 contains a heme cofactor. The protein is numbered by its gene.<ref>PMID:12369887</ref>.<br /> | ||
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</StructureSection> | </StructureSection> | ||
| - | == 3D Structures of Cytochrome P450 == | ||
| - | |||
| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | |||
| - | * human P450 1 family | ||
| - | |||
| - | **[[2hi4]] – hP4501A2+naphthoflavone - human<br /> | ||
| - | **[[4i8v]] - hP4501A1 +naphthoflavone<br /> | ||
| - | **[[6dwn]] - hP4501A1 + erlotinib<br /> | ||
| - | **[[6dwm]] - hP4501A1 + bergamottin<br /> | ||
| - | **[[3pm0]] - hP4501B1+naphthoflavone<br /> | ||
| - | **[[6iq5]] - hP4501B1 + inhibitor<br /> | ||
| - | |||
| - | * human P450 2 family | ||
| - | |||
| - | **[[2pg5]], [[2pg6]], [[2pg7]] – hP4502A6 (mutant)<br /> | ||
| - | **[[1pq2]] - hP4502C8<br /> | ||
| - | **[[1og2]], [[1og5]] – hP4502C9 (mutant)<br /> | ||
| - | **[[4gqs]] - hP4502C19 catalytic domain<br /> | ||
| - | **[[2f9q]], [[3qm4]] – hP4502D6<br /> | ||
| - | |||
| - | * human P450 2 family complex | ||
| - | |||
| - | **[[3ebs]] – hP4502A6 (mutant)+phenacetin<br /> | ||
| - | **[[2fdu]], [[2fdv]], [[2fdw]], [[2fdy]] - hP4502A6+pyridine derivative<br /> | ||
| - | **[[1z10]] - hP4502A6 catalytic domain+coumarin<br /> | ||
| - | **[[4ejj]] - hP4502A6 + nicotine<br /> | ||
| - | **[[3t3q]], [[3t3r]] - hP4502A6 (mutant) + pilocarpine<br /> | ||
| - | **[[2z10]] – hP4502A6+coumarin<br /> | ||
| - | **[[1z11]] - hP4502A6+methoxalen<br /> | ||
| - | **[[4rui]] – hP450 2A6 + volatile hydrocarbon<br /> | ||
| - | **[[3t3s]] - hP4502A13 + pilocarpine<br /> | ||
| - | **[[4ejg]] - hP4502A13 + nicotine<br /> | ||
| - | **[[4ejh]], [[4eji]] - hP4502A13 + pyridine derivative<BR /> | ||
| - | **[[2p85]] – hP4502A13 (mutant)+indole<br /> | ||
| - | **[[3ibd]] – hP4502B6 (mutant)+4-(4-chlorophenyl)imidazole<br /> | ||
| - | **[[3ua5]] – hP4502B6 (mutant) + amlodipine<br /> | ||
| - | **[[4i91]], [[4zv8]] - hP4502B6 (mutant) + pinine<br /> | ||
| - | **[[5wbg]] - hP4502B6 (mutant) + HIV drug<br /> | ||
| - | **[[3qoa]], [[2qu8]], [[3qu8]] – hP450 2B6 (mutant) + inhibitor<br /> | ||
| - | **[[4rql]], [[4rrt]] – hP450 2B6 (mutant) + volatile hydrocarbon<br /> | ||
| - | **[[5ufg]], [[5uec]], [[5uap]] – hP450 2B6 (mutant) + Br derivative<br /> | ||
| - | **[[5uda]] – hP450 2B6 (mutant) + monoterpene borane<br /> | ||
| - | **[[5e58]] – dwP450 2B35 + inhibitor – desert woodrat<br /> | ||
| - | **[[5e0e]] – dwP450 2B37 + inhibitor <br /> | ||
| - | **[[2nnh]] – hP4502C8+retinoic acid<br /> | ||
| - | **[[2nni]] - hP4502C8+montelukast<br /> | ||
| - | **[[2nnj]] - hP4502C8+felodipine<br /> | ||
| - | **[[1r9o]] – hP4502C9 (mutant)+flurbiprofen<br /> | ||
| - | **[[5xxi]], [[5x23]], [[5x24]] - hP4502C9 (mutant) + blood pressure drug<br /> | ||
| - | **[[5a5i]], [[5a5j]], [[5w0c]], [[5k7k]] - hP4502C9 + inhibitor<br /> | ||
| - | **[[4nz2]] - hP4502C9 (mutant) + inhibitor<br /> | ||
| - | **[[3tbg]], [[4wnw]] – hP4502D6 + thioridazine<br /> | ||
| - | **[[6csb]] - hP4502D6 (mutant) + thioridazine<br /> | ||
| - | **[[3tda]] – hP4502D6 + prinomastat<br /> | ||
| - | **[[6csd]] - hP4502D6 (mutant) + prinomastat<br /> | ||
| - | **[[4wnt]] - hP4502D6 + ajmalicine<br /> | ||
| - | **[[4wnu]], [[4wnv]] - hP4502D6 + quinine derivative<br /> | ||
| - | **[[5tft]], [[5tfu]], [[4xry]], [[4xrz]] - hP4502D6 + Bace1 inhibitor<br /> | ||
| - | **[[3gph]], [[3koh]], [[3lc4]] – hP4502E1 fragment +imidazole derivative<br /> | ||
| - | **[[3e6i]] – hP4502E1 fragment+indazole<br /> | ||
| - | **[[3e4e]] – hP4502E1 fragment+methylpyrazole<br /> | ||
| - | **[[3t3z]] - hP4502E1 + pilocarpine<br /> | ||
| - | **[[3czh]], [[3dl9]], [[3c6g]] – hP4502R1+vitamin D<br /> | ||
| - | |||
| - | * human P450 3 family | ||
| - | |||
| - | **[[1tqn]], [[1w0e]], [[1w0f]], [[1w0g]] – hP4503A4<br /> | ||
| - | **[[5vcc]], [[5vcd]], [[4l3q]] - hP4503A4 (mutant) <br /> | ||
| - | **[[2v0m]] – hP4503A4+ anti-fungal drug<br /> | ||
| - | **[[2j0d]] - hP4503A4+ antibiotic<br /> | ||
| - | **[[3nxu]], [[3tjs]] - hP4503A4+ anti-HIV drug<br /> | ||
| - | **[[4i4g]], [[4i4h]], [[4k9t]], [[4k9u]], [[4k9v]], [[4k9w]], [[4k9x]], [[5vc0]], [[5vce]] - hP4503A4 (mutant) + anti-HIV drug<br /> | ||
| - | **[[5g5j]] - hP4503A4 + anti-diabetic drug<br /> | ||
| - | **[[3ua1]] - hP4503A4 + ergocryptine<br /> | ||
| - | **[[5vcg]] - hP4503A4 (mutant) + ergocryptine<br /> | ||
| - | **[[4ny4]], [[4d7d]], [[4d78]], [[4d75]], [[4d6z]], [[6bdm]], [[6bdk]], [[6bdi]], [[6bdh]], [[6bd8]], [[6bd7]], [[6bd6]], [[6bd5]], [[6bcz]], [[6ma8]], [[6ma7]], [[6ma6]], [[6dal]], [[6daj]], [[6dag]], [[6dac]], [[6dab]], [[6daa]], [[6da8]], [[6da5]], [[6da3]], [[6da2]] - hP4503A4 + inhibitor <br /> | ||
| - | **[[5te8]] - hP4503A4 + sedation drug <br /> | ||
| - | **[[5a1p]], [[5a1r]] - hP4503A4 + progesterone <br /> | ||
| - | **[[6mjm]] - hP4503A5 <br /> | ||
| - | **[[5veu]] - hP4503A5 + inhibitor<br /> | ||
| - | |||
| - | * human P450 7 family | ||
| - | |||
| - | **[[3dax]] – hP4507A1<br /> | ||
| - | **[[3sn5]] - hP4507A1 + cholest-4-en-3-one | ||
| - | |||
| - | *human P450 11 family | ||
| - | |||
| - | **[[6m7x]] - hP450 CYP11B1 + fadrozole<br /> | ||
| - | **[[4dvq]] - hP450 CYP11B2 + corticosterone<br /> | ||
| - | **[[4fdh]] - hP450 CYP11B2 + fadrozole<br /> | ||
| - | **[[4zgx]] - hP450 CYP11B2 + inhibitor<br /> | ||
| - | |||
| - | * human P450 17 A1 family (steroid 17-α-hydroxylase 17,20 lyase) | ||
| - | |||
| - | **[[5uys]], [[3ruk]] - hP450 C17 + abiraterone derivative<br /> | ||
| - | **[[4nkv]] - hP450 C17 (mutant) + abiraterone derivative<br /> | ||
| - | **[[5irq]] - hP450 C17 + orteronel<br /> | ||
| - | **[[5irv]] - hP450 C17 + inhibitor<br /> | ||
| - | **[[4nkw]], [[4nkz]] - hP450 C17 (mutant) + pregnenolone derivative<br /> | ||
| - | **[[4nkx]], [[4nky]] - hP450 C17 (mutant) + progesterone derivative<br /> | ||
| - | **[[3swz]] - hP450 C17 + drug<br /> | ||
| - | |||
| - | * human P450 19 family (aromatase) | ||
| - | |||
| - | **[[5jkv]] - hP45019A1<br /> | ||
| - | **[[5jkw]] - hP45019A1 + testosterone<br /> | ||
| - | **[[3eqm]], [[3s79]], [[4kq8]], [[5jl6]], [[5jl7]], [[5jl9]] - hP45019A1+androstenedione<br /> | ||
| - | **[[3s7s]] - hP45019A1 + exemestane<br /> | ||
| - | **[[4gl5]], [[4gl7]] - hP45019A1 + inhibitor | ||
| - | |||
| - | * human P450 46 family | ||
| - | |||
| - | **[[2q9f]] – hP45046A1+cholesterol<br /> | ||
| - | **[[2q9d]], [[2q9g]] - hP45046A1<br /> | ||
| - | **[[2vn0]] – hP450105A1+troglitazone<br /> | ||
| - | **[[2zby]] - hP450105A1 (mutant) | ||
| - | |||
| - | * P450 from ''Mycobacterium tuberculosis'' or sterol 14-α demethylase | ||
| - | |||
| - | **[[2vku]], [[1h5z]] – MtP450 CYP51 - ''Mycobacterium tuberculosis''<br /> | ||
| - | **[[2ci0]], [[2cib]], [[1u13]] - MtP450 CYP51 (mutant)<br /> | ||
| - | **[[1x8v]] - MtP450 CYP51 (mutant)+estriol<br /> | ||
| - | **[[1ea1]] - MtP450 CYP51 (mutant)+ fluconazole<br /> | ||
| - | **[[1e9x]] - MtP450 CYP51 (mutant)+ phenylimidazole<br /> | ||
| - | **[[3cxv]], [[3cxx]], [[3cxy]], [[3cxz]], [[3cy0]], [[3cy1]] - MtP450 CYP121 (mutant)<br /> | ||
| - | **[[3g5f]], [[3g5h]], [[2ij5]], [[1n40]] – MtP450 CYP121<br /> | ||
| - | **[[2ij7]] - MtP450 CYP121+fluconazole<br /> | ||
| - | **[[1n4g]], [[4ktf]], [[4ktj]], [[4ktk]], [[4ktl]] - MtP450 CYP121+pyrazole derivative<br /> | ||
| - | **[[4ict]], [[4ips]], [[4ipw]], [[4iq7]], [[4iq9]] - MtP450 CYP121 + piperazine derivative<br /> | ||
| - | **[[4g1x]], [[4g2g]], [[4g44]], [[4g45]], [[4g46]], [[4g47]], [[4g48]], [[5ibg]], [[5ibh]], [[5ibi]], [[5ibj]], [[5ibd]], [[5ibe]], [[5ibf]], [[5edt]] - MtP450 CYP121 + inhibitor<br /> | ||
| - | **[[3ivi]], [[3iw0]], [[3ivy]] – MtP450 CYP125 <br /> | ||
| - | **[[3iw1]] - MtP450 CYP125+androstenedione<br /> | ||
| - | **[[3iw2]] - MtP450 CYP125+econazole<br /> | ||
| - | **[[2uvn]] - MtP450 CYP130+econazole<br /> | ||
| - | **[[2wgy]] – MtP450 CYP130 (mutant)<br /> | ||
| - | **[[2w09]], [[2w0b]], [[2w0a]] - MtP450 CYP130 (mutant)+pyridine inhibitor<br /> | ||
| - | **[[2uuq]] – MtP450 CYP130<br /> | ||
| - | **[[5hdi]] - MtP450 CYP144A1<br /> | ||
| - | |||
| - | * P450cam or camphor-5 momooxygenase | ||
| - | |||
| - | **[[2qbl]], [[2qbm]], [[2qbn]], [[2gqx]], [[2gr6]], [[2frz]], [[2h7s]], [[6cp4]], [[2cp4]], [[3cp4]], [[4cp4]], [[1c8j]], [[1geb]], [[2a1o]], [[3p6q]], [[3p6r]], [[3p6s]], [[3p6t]], [[3p6u]], [[3p6v]], [[3p6w]], [[3p6x]], [[4ek1]], [[5wk7]] – PpP450cam(mutant) – ''Pseudomona putida''<br /> | ||
| - | **[[1dz4]], [[1dz8]], [[1dz6]], [[1dz9]], [[5cp4]], [[1phc]], [[2cpp]], [[1yrc]], [[1yrd]], [[3l61]], [[3l62]], [[3l63]], [[3wrh]], [[3wri]], [[3wrk]] - PpP450cam<br /> | ||
| - | **[[2qbo]] - PpP450cam (mutant)+cyanide<br /> | ||
| - | **[[1qmq]] - PpP450cam (mutant)+Ru substrate<br /> | ||
| - | **[[2h7q]] - PpP450cam+imidazole<br /> | ||
| - | **[[1cp4]] - PpP450cam+benzene<br /> | ||
| - | **[[1akd]], [[1iwi]], [[1noo]], [[7cpp]], [[8cpp]], [[2zwt]], [[2zwu]], [[5ik1]] - PpP450cam+1S-camphor derivative<br /> | ||
| - | **[[1iwj]], [[1iwk]], [[2zuh]], [[2zui]], [[2zuj]], [[3fwf]], [[3fwg]], [[3fwi]], [[3fwj]] - PpP450cam (mutant)+1Scamphor<br /> | ||
| - | **[[4l49]], [[4l4a]], [[4l4b]], [[4l4c]] - PpP450cam (mutant)+ camphor<br /> | ||
| - | **[[4l4d]], [[4l4e]], [[4l4f]], [[4l4g]], [[5wk9]] - PpP450cam (mutant)+ camphor + CN<br /> | ||
| - | **[[4kky]] - PpP450cam (mutant)+ camphor + pyrene derivative<br /> | ||
| - | **[[2l8m]] – PpP450cam+camphor+CO<br /> | ||
| - | **[[4g3r]] – PpP450cam+camphor+NO<br /> | ||
| - | **[[2fe6]], [[2fer]], [[2feu]] - PpP450cam+Mn protoporphyrin IX<br /> | ||
| - | **[[1uyu]] - PpP450cam+ Xe<br /> | ||
| - | **[[1o76]] - PpP450cam+cyanide<br /> | ||
| - | **[[4cpp]] - PpP450cam+adamantine<br /> | ||
| - | **[[5cpp]] - PpP450cam+adamantanone<br /> | ||
| - | **[[6cpp]] - PpP450cam+camphene<br /> | ||
| - | **[[1p2y]], [[1p7r]] - PpP450cam+nicotine<br /> | ||
| - | **[[1re9]], [[1rf9]] - PpP450cam +fluorescent probe<br /> | ||
| - | **[[2z97]], [[2zaw]], [[2zax]] - PpP450cam+methyl depropionated hemin<br /> | ||
| - | **[[3cpp]], [[2lqd]] - PpP450cam+CO<br /> | ||
| - | **[[1pha]], [[1phb]], [[1phd]], [[1phe]], [[1phf]], [[1phg]] - PpP450cam+imidazole derivative<br /> | ||
| - | **[[1gek]], [[1gem]] - PpP450cam+N-butyl-isocyanide<br /> | ||
| - | **[[1lwl]] - PpP450cam+fluorescent probe<br /> | ||
| - | **[[2h7r]] - PpP450cam (mutant)+imidazole<br /> | ||
| - | **[[1k2o]] - PpP450cam (mutant)+pyridine derivative<br /> | ||
| - | **[[1gjm]] - PpP450cam (mutant)+sulphydryl reagent<br /> | ||
| - | **[[2a1m]], [[2a1n]], [[2a10]] - PpP450cam (mutant)+ferrous dioxygen<br /> | ||
| - | **[[1t85]], [[1t86]], [[1t87]], [[1t88]] - PpP450cam (mutant)+ferrous CO<br /> | ||
| - | **[[1j51]] - PpP450cam (mutant)+trichlorobenzene<br /> | ||
| - | **[[1mpw]] - PpP450cam (mutant)+trimethylbicycloheptene<br /> | ||
| - | **[[3oia]], [[3ol5]], [[3p6m]], [[3p6n]], [[3p6o]], [[3p6p]], [[3poq]], [[3por]], [[3pos]], [[3pot]], [[3pou]], [[3pov]], [[3pow]], [[3pox]], [[3w9c]], [[5gxg]] - PpP450cam (mutant)+substrate analog<br /> | ||
| - | **[[4jws]], [[4jwu]] - PpP450cam (mutant)+ putidaredoxin<br /> | ||
| - | **[[4jx1]] - PpP450cam (mutant)+ putidaredoxin + camphor + hydroxycamphor<br /> | ||
| - | **[[4jx1]] - PpP450cam (mutant)+ putidaredoxin + camphor + CN<br /> | ||
| - | **[[2m56]] - PpP450cam + putidaredoxin + camphor <br /> | ||
| - | **[[3oft]], [[4c9m]], [[3lxh]], [[3lxi]], [[3ofu]], [[6hqw]] – NaP450 – ''Novosphignobium aromaticivorans''<br /> | ||
| - | **[[4c9p]] - NaP450cam (mutant) + camphor <br /> | ||
| - | **[[4c9k]] - NaP450cam + camphor + hydroxycamphor<br /> | ||
| - | **[[4c9n]] - NaP450cam (mutant) + camphor + hydroxycamphor<br /> | ||
| - | **[[4c9l]] - NaP450cam + camphor + CN<br /> | ||
| - | **[[4c9o]] - NaP450cam (mutant) + camphor + CN<br /> | ||
| - | |||
| - | * P450nor or NADP nitrous oxide-forming nitric-oxide reductase or nitric oxide reductase | ||
| - | |||
| - | **[[1cl6]], [[1rom]], [[5y5j]], [[5y5l]], [[1jfb]], [[1jfc]], [[1ged]], [[1ehe]] – FoP450nor - ''Fusarium oxysporum''<br /> | ||
| - | **[[2rom]] - FoP450nor+CO<br /> | ||
| - | **[[5y5f]], [[5y5g]], [[5y5h]], [[5y5k]] – FoP450nor + NO<br /> | ||
| - | **[[1f24]], [[1f25]], [[1f26]] – FoP450nor (mutant) + NO<br /> | ||
| - | **[[5y5i]] – FoP450nor + NO + NADH<br /> | ||
| - | **[[1cmj]], [[1cmn]], [[1ehg]], [[1ehf]], [[1ulw]] - FoP450nor (mutant)<br /> | ||
| - | **[[1xqd]] – FoP450nor+pyridinealdehyde adenine<br /> | ||
| - | **[[1gej]], [[1gei]] - FoP450nor+N-butyl-isocyanide<br /> | ||
| - | |||
| - | *P450epoK | ||
| - | |||
| - | **[[1q5e]] - ScP450epoK - ''Sorangium cellulosum''<br /> | ||
| - | **[[1q5d]], [[1pkf]] – ScP450epoK+epothilone <br /> | ||
| - | |||
| - | *P450cin | ||
| - | |||
| - | **[[3bdz]], [[3be0]], [[4fyz]], [[4fb2]] – CbP450cin – ''Citrobacter braakii''<br /> | ||
| - | **[[4lht]], [[4l77]] - CbP450cin (mutant)<br /> | ||
| - | **[[4fmx]], [[1t2b]] – CbP450cin + cineole<br /> | ||
| - | **[[4l6g]] – CbP450cin (mutant) + cineole<br /> | ||
| - | |||
| - | * rabbit P450 | ||
| - | |||
| - | **[[2bdm]] – rP450 CYP2B4 – rabbit<br /> | ||
| - | **[[1po5]], [[3mvr]], [[3r1a]], [[3r1b]], [[5iut]], [[5iuz]], [[5em4]], [[6bww]] - rP450 CYP2B4 (mutant)<br /> | ||
| - | **[[1suo]],[[3g5n]], [[3g93]], [[2q6n]], [[3tk3]] - rP450 CYP2B4 (mutant)+imidazole derivative<br /> | ||
| - | **[[4mgj]] - rP450 CYP2B4 (mutant)+ thiol derivative<br /> | ||
| - | **[[3kw4]], [[3me6]], [[3tmz]], [[4h1n]] - rP450 CYP2B4 (mutant)+anti-platelet drug<br /> | ||
| - | **[[4jlt]] - rP450 CYP CYP2B4 (mutant) + anti-depressant drug<br /> | ||
| - | **[[3uas]] - rP450 CYP CYP2B4 (mutant)+ inactivator<br /> | ||
| - | **[[5t6q]] - rP450 CYP4B1 + octane<br /> | ||
| - | **[[6c93]] - rP450 CYP4B1 (mutant) + octane<br /> | ||
| - | **[[6c94]] - rP450 CYP4B1 + inhibitor<br /> | ||
| - | **[[1dt6]] - rP450 CYP2C5 (mutant)<br /> | ||
| - | **[[1nr6]] – rP450 CYP2C5+diclofenac<br /> | ||
| - | **[[1n6b]] - rP450 CYP2C5+sulfaphenazole | ||
| - | |||
| - | *P450 BM3 or bifunctional P450/NADPH-P450 reductase; Domains – heme 1-458; FMN 459-647; FAD 659-1049 | ||
| - | |||
| - | **[[3cbd]], [[2bmh]], [[2j4s]], [[4zfa]], [[1bu7]] – BmP450 heme domain – ''Bacillus megaterium''<br /> | ||
| - | **[[5zlh]], [[5zis]] - BmP450 heme domain + Mn-protoporphyrin<br /> | ||
| - | **[[3dgi]], [[3hf2]], [[3kx3]], [[3kx4]], [[3kx5]], [[3m4v]], [[3npl]], [[3psx]], [[4dty]], [[4dua]], [[4duc]], [[4dud]], [[1jme]], [[1p0v]], [[1p0w]], [[1p0x]], [[1smi]], [[1yqp]], [[1yqo]], [[1zo4]], [[2nnb]], [[4hgj]], [[4h23]], [[4h24]], [[4kpb]], [[4kf0]], [[4kf2]], [[4wg2]], [[1fah]], [[4rsn]], [[4zf6]], [[5dyp]], [[5e7y]], [[5e9z]], [[5jqu]], [[5jqv]], [[5ucw]] - BmP450 heme domain (mutant)<br /> | ||
| - | **[[4dtw]], [[4due]], [[4duf]] - BmP450 heme domain (mutant) + serotonin<br /> | ||
| - | **[[4dtz]], [[4du2]], [[4dub]] - BmP450 heme domain (mutant) + dopamine<br /> | ||
| - | **[[1jpz]], [[1zo9]], [[1zoa]], [[4kpa]] - BmP450 heme domain + palmitate derivative<br /> | ||
| - | **[[1smj]], [[5jq2]] - BmP450 heme domain (mutant) + palmitate derivative<br /> | ||
| - | **[[2x7y]], [[2x80]] - BmP450 heme domain (mutant) + DMSO<br /> | ||
| - | **[[4hgf]], [[4hgg]], [[4hgh]], [[4hgi]] - BmP450 heme domain (mutant) + styrene<br /> | ||
| - | **[[4kew]], [[4key]], [[4o4p]], [[4zf8]], [[6h1l]], [[6h1o]], [[6h1s]], [[6h1t]] - BmP450 heme domain (mutant) + drug<br /> | ||
| - | **[[3ekb]], [[3ekd]], [[3ekf]], [[2ij3]], [[2ij4]] - BmP450102 heme domain (mutant)<br /> | ||
| - | **[[2ij2]], [[2hpd]] - BmP450102 heme domain<br /> | ||
| - | **[[4dqk]] - BmP450 FAD domain + FAD<br /> | ||
| - | **[[4dql]] - BmP450 FAD domain + NADP + FAD<br /> | ||
| - | **[[3wsp]] - BmP450 heme domain + decoy molecule<br /> | ||
| - | **[[2uwh]] - BmP450102+palmitic acid<br /> | ||
| - | **[[3ben]] - BmP450 heme domain + inhibitor<br /> | ||
| - | **[[2j1m]] - BmP450102 heme domain +DMSO<br /> | ||
| - | **[[5jtd]] - BmP450102 heme domain (mutant) +DMSO<br /> | ||
| - | **[[1bvy]] – BmP450102A1 heme+FMN domains<br /> | ||
| - | **[[5e78]] - BmP450 heme domain + Co + sepulchrate<br /> | ||
| - | **[[1fag]] – BmP450102A1 heme domain + palmitate<br /> | ||
| - | **[[4zfb]], [[5dyz]] - BmP450 (mutant) + palmitate<br /> | ||
| - | **[[5b2v]], [[5b2y]], [[5xa3]], [[5xhj]] - BmP450 heme domain + amino acid derivative<br /> | ||
| - | **[[5og9]] - BmP450 heme domain + testosterone<br /> | ||
| - | **[[5b2u]], [[5b2w]], [[5b2x]] - BmP450 heme domain (mutant) + tryptophan derivative<br /> | ||
| - | **[[4yt3]] - BmP450 CYP106A2 <br /> | ||
| - | **[[5iki]] - BmP450 CYP106A2 + abietic acid <br /> | ||
| - | **[[5l90]] - BmP450 CYP109E1 <br /> | ||
| - | **[[5l91]], [[5l92]] - BmP450 CYP109E1 + corticosterone<br /> | ||
| - | **[[5l94]] - BmP450 CYP109E1 + testosterone<br /> | ||
| - | |||
| - | * Other CYPs | ||
| - | |||
| - | **[[1ued]] – AoP450 oxyC – ''Amycolatopsis orientalis''<br /> | ||
| - | **[[1lfk]], [[1lg9]], [[1lgf]] - AoP450 oxyB<br /> | ||
| - | **[[5ex6]], [[5ex9]], [[5ex8]] - P450 – ''Streptomyces toyocaensis''<br /> | ||
| - | **[[5vws]] - P450 – ''Thermobispora bispora''<br /> | ||
| - | **[[3p3l]], [[3p3o]], [[3p3x]], [[3p3z]] – P450 – ''Streptomyces thioluteus''<br /> | ||
| - | **[[2rfb]] – PtP450 – ''Picrophilus torridus''<br /> | ||
| - | **[[6gii]] – P450 – ''Tepidiphilus thermophilus''<br /> | ||
| - | **[[1wiy]] – TtP450 – ''Thermus thermophilus''<br /> | ||
| - | **[[4e2p]], [[5xw2]] - P450 – ''Streptococcus himastatinicus''<br /> | ||
| - | **[[6g5q]], [[6g5o]] - P450 – ''Zobellia galactanivorans''<br /> | ||
| - | **[[5ysm]] – AmP450 – ''Amycolatopsis mediterranei''<br /> | ||
| - | **[[6f0c]], [[6f0b]] - P450 TXTC – ''Streptomyces acidiscabies''<br /> | ||
| - | **[[5gwe]] – CgP450 CREJ – ''Corynebacterium glutamicum''<br /> | ||
| - | **[[5y1i]] - P450 GFSF – ''Streptomyces graminofaciens''<br /> | ||
| - | **[[1cpt]] – PsP450 TERP - ''Pseudomonas sp.''<br /> | ||
| - | **[[4l0e]], [[4l0f]] - StP450 SKY32– ''Streptomyces''<br /> | ||
| - | **[[3awp]], [[3awq]] - SpP450-α (mutant) - ''Sphingomonas paucimobilis''<br /> | ||
| - | **[[3a4g]], [[3a4h]] – PaP450 VDH – ''Pseudonocardia autotrophica''<br /> | ||
| - | **[[3a4z]], [[5gnm]], [[5gnl]] - PaP450 VDH (mutant)<br /> | ||
| - | **[[3qi8]] – P450 – synthetic<br /> | ||
| - | **[[3dam]], [[3dan]], [[3dbm]] – P45074A2 – ''Parthenium argentatum''<br /> | ||
| - | **[[2rcm]], [[3cli]] - AtP45074A - ''Arabidopsis thaliana''<br /> | ||
| - | **[[5kyo]] - P450 CYP101J2 – ''Sphingobium yanoikuyae''<br /> | ||
| - | **[[3nv5]], [[3nv6]], [[4dxy]] - NaP450 CYP101D2<br /> | ||
| - | **[[4oqs]] - AoP450 CYP105AS1<br /> | ||
| - | **[[3abb]] – SaP450 CYP105D6 - ''Streptomyces avermitilis''<br /> | ||
| - | **[[3e5j]], [[3e5l]] - SaP450 CYP105P1 (mutant)<br /> | ||
| - | **[[2z3u]] - SsP450 CYP105A1 (mutant) – ''Streptomyces griseolus''<br /> | ||
| - | **[[5xnt]] - P450 CYP106A2 – ''Bacillus butanolivorans''<br /> | ||
| - | **[[4wpz]] - SaP450 CYP107W1 <br /> | ||
| - | **[[2whw]], [[2wi9]], [[2vz7]] – SvP450107L1 (mutant) – ''Streptomyces venezuelae''<br /> | ||
| - | **[[2bvj]] - SvP450107L1<br /> | ||
| - | **[[3tkt]] – NaP450 CYP108D1<br /> | ||
| - | **[[5ofq]] - BmP450 CYP109A2<br /> | ||
| - | **[[4rm4]] - BsP450 CYP109B1<br /> | ||
| - | **[[2jjn]], [[2jjo]] - SeP450 CYP113A1 (mutant) - ''Saccharopolyspora erythraea''<br /> | ||
| - | **[[1io8]], [[5bv5]] – SsP450 CYP119 (mutant) – ''Sulfolobus solfataricus''<br /> | ||
| - | **[[1io9]], [[1io7]], [[1f4u]] - SsP450 CYP119<br /> | ||
| - | **[[6cvc]] – MmP450 CYP124A1 – ''Mycobacterium marinum''<br /> | ||
| - | **[[5dqn]] - MsP450 CYP125A3 (mutant) – ''Mycobacterium smegmatis''<br /> | ||
| - | **[[3nc3]], [[3nc5]], [[3nc6]], [[3nc7]] - BsP450 CYP134A1 (mutant)<br /> | ||
| - | **[[2zqj]] – BsP450152A1 – ''Bacillus subtilis''<br /> | ||
| - | **[[5fyf]] - MhP450 CYP153A – ''Marinobacter hydrocarbonoclasticus''<br /> | ||
| - | **[[6hqg]] - P450 CYP153 – ''Phenylobacterium zucineum''<br /> | ||
| - | **[[6hqd]] – PsP450 CYP153 <br /> | ||
| - | **[[1gwi]] - ScP450 CYP154C1<br /> | ||
| - | **[[6a7i]] - SvP450 CYP154C4 – ''Streptomyces violaceruber''<br /> | ||
| - | **[[2nz5]], [[2nza]], [[2dkk]] – ScP450 CYP158A1 – ''Streptomyces coelicolor''<br /> | ||
| - | **[[3r9b]] – MsP450 CYP164A2 <br /> | ||
| - | **[[6dcd]] – MmP450 CYP164A6 <br /> | ||
| - | **[[3o1a]] – P450 CYP165D3 – ''Actinoplanes teichomyceticus''<br /> | ||
| - | **[[1n97]] – TtP450 CYP175A1<br /> | ||
| - | **[[4dnz]] – RpP450 CYP199A4 – ''Rhodopseudomonas palustris''<br /> | ||
| - | **[[2z3t]] - StrP450 CYP245A1 - ''Streptomyces sp.''<br /> | ||
| - | **[[5liv]] - ScP450 CYP260A1 <br /> | ||
| - | **[[6f85]] - ScP450 CYP260A1 (mutant)<br /> | ||
| - | **[[5hiw]] - ScP450 CYP260B1 <br /> | ||
| - | **[[6gk5]] - ScP450 CYP267B1 <br /> | ||
| - | **[[6g71]] - P450 CYP1232A24 - ''Arthrobacter''<br /> | ||
| - | |||
| - | *Other CYPs complexes | ||
| - | |||
| - | **[[2rfc]] – PtP450+phenylimidazole<br /> | ||
| - | **[[3wec]] – P450 + dihydroxy-aurachin Re – ''Rhodococcus erythropolis''<br /> | ||
| - | **[[5ysw]] – AmP450+ rifamycin <br /> | ||
| - | **[[5omu]] – AmP450+ syringol <br /> | ||
| - | **[[5oms]] – AmP450+ guaethol <br /> | ||
| - | **[[5ncb]] – AmP450+ guayacol <br /> | ||
| - | **[[5omr]] – AmP450+ vanilin <br /> | ||
| - | **[[4pwv]], [[4pxh]] - StP450 SKY32 + peptidyl carrier protein domain<br /> | ||
| - | **[[2zqx]] - BsP450 BS b +heptanoic acid<br /> | ||
| - | **[[1izo]] – BsP450 BS beta+ palmitoleic acid<br /> | ||
| - | **[[3awm]] – SpP450-α + palmitic acid <br /> | ||
| - | **[[3a50]], [[3a51]] - PaP450 VDH (mutant) + vitamin D3<br /> | ||
| - | **[[5xjn]] – CgP450 CREJ + ethylphenyl derivative<br /> | ||
| - | **[[5fsa]] – P450 CYP51 (mutant) + posaconazole – ''Candida albicans''<br /> | ||
| - | **[[2rch]], [[3dsi]] – AtP450 CYP74A+13(S)-HOD <br /> | ||
| - | **[[3dsj]] - AtP450 CYP74A (mutant)+13(S)-HOD<br /> | ||
| - | **[[2rcl]] - AtP450 CYP74A+vernolic acid<br /> | ||
| - | **[[3dsk]] - AtP450 CYP74A (mutant)+ vernolic acid<br /> | ||
| - | **[[3cv9]], [[2zbz]] - SgP450 CYP105A1 (mutant)+vitamin D3<br /> | ||
| - | **[[2zbx]] - SgP450 CYP105A1+imidazole<br /> | ||
| - | **[[5x7e]] - SsP450 CYP105A1 (mutant)+vitamin D2<br / | ||
| - | **[[3aba]] – SaP450 CYP105P1+filipin I <br /> | ||
| - | **[[3e5k]] - SaP450 CYP105P1 (mutant)+4-phenylimidazole<br /> | ||
| - | **[[4oqr]] - AoP450 CYP105AS1 (mutant) + compactin<br /> | ||
| - | **[[1jin]], [[1jip]] - SeP450 CYP107A1+ ketoconazole <br /> | ||
| - | **[[1jio]], [[1oxa]] - SeP450 CYP107A1+6DEB<br /> | ||
| - | **[[1eup]] – SeP450 CYP107A1+androstendione<br /> | ||
| - | **[[1egy]] - SeP450 CYP107A1+aminophenanthrene<br /> | ||
| - | **[[4wq0]] - SaP450 CYP107W1 + oligomycin<br /> | ||
| - | **[[2vzm]] – SvP450 CYP107L1 (mutant)+narbomycin<br /> | ||
| - | **[[2c7x]] - SvP450 CYP107L1+narbomycin<br /> | ||
| - | **[[2cd8]], [[2ca0]], [[2c6h]] – SvP450 CYP107L1+YC-17<br /> | ||
| - | **[[2jjp]] - SeP450 CYP113A1 (mutant)+ketoconazole<br /> | ||
| - | **[[2xfh]] - SeP450 CYP113A1 (mutant)+clotrimazole<br /> | ||
| - | **[[1f4t]] - SsP450 CYP119+ phenylimidazole<br /> | ||
| - | **[[4tt5]], [[4tuv]], [[4wpd]], [[4wqj]] - P450 CYP119+ imidazole derivative – ''Sulfolobus acidocaldarius''<br /> | ||
| - | **[[5yhj]] - P450 CYP152N1 + myristic acid - ''Exiguobacterium''<br /> | ||
| - | **[[5fyg]] - MhP450 CYP153A + dodecanoic acid<br /> | ||
| - | **[[6a7j]] - SvP450 CYP154C4 + testosterone <br /> | ||
| - | **[[3r9c]] – MsP450 CYP164A2 + econazole<br /> | ||
| - | **[[4do1]], [[4egm]], [[6c3j]], [[6c3h]], [[6c2d]], [[5yqh]], [[5yqa]], [[5uvb]], [[5u6w]], [[5u6u]], [[5u6t]], [[5kt1]], [[5kdb]] – RpP450 CYP199A4 + benzoate derivative<br /> | ||
| - | **[[5kdz]], [[5kdy]] – RpP450 CYP199A4 (mutant) + benzoate derivative<br /> | ||
| - | **[[4egn]] – RpP450 CYP199A4 + veratric acid<br /> | ||
| - | **[[4egp]] – RpP450 CYP199A4 + naphthoic acid<br /> | ||
| - | **[[4ego]] – RpP450 CYP199A4 + indole derivative<br /> | ||
| - | **[[3a1l]] – StrP450 CYP245A1+dichlorochrompyrrolic acid <br /> | ||
| - | **[[6f88]], [[6f8c]] - ScP450 CYP260A1 (mutant) + progesterone<br /> | ||
| - | **[[6f8a]] - ScP450 CYP260A1 (mutant) + histidine<br /> | ||
| - | **[[6gk6]] - ScP450 CYP267B1 + myristic acid<br /> | ||
| - | **[[6bld]] - MmP450 CYP268A2 + pseudoionone<br /> | ||
| - | **[[4r20]] - zP450 17A2 + abiraterone – zebra fish<br /> | ||
| - | **[[6b82]] - zP450 17A1 (mutant) + abiraterone <br /> | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 10:21, 28 May 2019
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References
- ↑ Danielson PB. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab. 2002 Dec;3(6):561-97. PMID:12369887
- ↑ Williams PA, Cosme J, Ward A, Angove HC, Matak Vinkovic D, Jhoti H. Crystal structure of human cytochrome P450 2C9 with bound warfarin. Nature. 2003 Jul 24;424(6947):464-8. Epub 2003 Jul 13. PMID:12861225 doi:http://dx.doi.org/10.1038/nature01862
