6rs4
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of tabersonine synthase - an alpha-beta hydrolase from Catharanthus roseus== | |
| + | <StructureSection load='6rs4' size='340' side='right'caption='[[6rs4]], [[Resolution|resolution]] 1.30Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6rs4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RS4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RS4 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rs4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rs4 OCA], [http://pdbe.org/6rs4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rs4 RCSB], [http://www.ebi.ac.uk/pdbsum/6rs4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rs4 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TS_CATRO TS_CATRO]] Component of iboga and aspidosperma monoterpenoid indole alkaloids (MIAs, e.g. tabersonine and catharanthine) biosynthesis pathway from 19E-geissoschizine. Catalyzes the conversion of O-acetylstemmadenine (OAS) to tabersonine, a precursor of vindoline.<ref>PMID:29511102</ref> <ref>PMID:29724909</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Cycloaddition reactions generate chemical complexity in a single step. Here we report the crystal structures of three homologous plant-derived cyclases involved in the biosynthesis of iboga and aspidosperma alkaloids. These enzymes act on the same substrate, named angryline, to generate three distinct scaffolds. Mutational analysis reveals how these highly similar enzymes control regio- and stereo-selectivity. | ||
| - | + | Structural basis of cycloaddition in biosynthesis of iboga and aspidosperma alkaloids.,Caputi L, Franke J, Bussey K, Farrow SC, Vieira IJC, Stevenson CEM, Lawson DM, O'Connor SE Nat Chem Biol. 2020 Feb 17. pii: 10.1038/s41589-019-0460-x. doi:, 10.1038/s41589-019-0460-x. PMID:32066966<ref>PMID:32066966</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 6rs4" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bussey, K]] | ||
| + | [[Category: Caputi, L]] | ||
| + | [[Category: Connor, S E.O]] | ||
| + | [[Category: Farrow, S C]] | ||
| + | [[Category: Franke, J]] | ||
| + | [[Category: Lawson, D M]] | ||
| + | [[Category: Stevenson, C E.M]] | ||
| + | [[Category: Vieira, I J.Curcino]] | ||
| + | [[Category: Alkaloid]] | ||
| + | [[Category: Alpha/beta hydrolase fold]] | ||
| + | [[Category: Biosynthesis]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Natural product]] | ||
| + | [[Category: Tabersonine]] | ||
Revision as of 06:48, 4 March 2020
Structure of tabersonine synthase - an alpha-beta hydrolase from Catharanthus roseus
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