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5npm

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Current revision (13:20, 15 November 2023) (edit) (undo)
 
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<StructureSection load='5npm' size='340' side='right'caption='[[5npm]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='5npm' size='340' side='right'caption='[[5npm]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5npm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/"flavobacterium_thermophilum"_yoshida_and_oshima_1971 "flavobacterium thermophilum" yoshida and oshima 1971]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NPM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NPM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5npm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NPM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NPM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">rplA, rpl1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 "Flavobacterium thermophilum" Yoshida and Oshima 1971])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5npm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5npm OCA], [http://pdbe.org/5npm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5npm RCSB], [http://www.ebi.ac.uk/pdbsum/5npm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5npm ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5npm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5npm OCA], [https://pdbe.org/5npm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5npm RCSB], [https://www.ebi.ac.uk/pdbsum/5npm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5npm ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RL1_THETH RL1_THETH]] The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.[HAMAP-Rule:MF_01318] Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA (By similarity).[HAMAP-Rule:MF_01318]
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[https://www.uniprot.org/uniprot/RL1_THET8 RL1_THET8] Directly binds to 23S rRNA. Forms what is known as the L1 stalk, which protrudes beyond the 70S ribosome surface. The stalk is preferentially stabilized in 70S versus 50S crystals. Interacts with the E site tRNA, blocking the exit path. This blockage implies that this section of the ribosome must be able to move to release the deacetylated tRNA.[HAMAP-Rule:MF_01318_B] Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA (By similarity).[HAMAP-Rule:MF_01318_B]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5npm" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5npm" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Ribosomal protein L1|Ribosomal protein L1]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Flavobacterium thermophilum yoshida and oshima 1971]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Gabdulkhakov, A G]]
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[[Category: Thermus thermophilus]]
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[[Category: Garber, M B]]
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[[Category: Gabdulkhakov AG]]
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[[Category: Nevskaya, N A]]
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[[Category: Garber MB]]
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[[Category: Nikonov, S V]]
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[[Category: Nevskaya NA]]
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[[Category: Tishchenko, T V]]
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[[Category: Nikonov SV]]
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[[Category: 23s rrna]]
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[[Category: Tishchenko TV]]
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[[Category: L1 stalk]]
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[[Category: Ribosome]]
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[[Category: Rna]]
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Current revision

CRYSTAL STRUCTURE OF MUTANT RIBOSOMAL PROTEIN TTHL1 LACKING 8 N-TERMINAL RESIDUES IN COMPLEX WITH 80NT 23S RNA FROM THERMUS THERMOPHILUS

PDB ID 5npm

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