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| - | | + | #REDIRECT [[6eyf]] This PDB entry is obsolete and replaced by 6eyf |
| - | ==Butyrylcolinesterase expressed in CHO cells co-crystallised with a rivastigmine analogue==
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| - | <StructureSection load='6eul' size='340' side='right'caption='[[6eul]], [[Resolution|resolution]] 2.60Å' scene=''>
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| - | == Structural highlights ==
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| - | <table><tr><td colspan='2'>[[6eul]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EUL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EUL FirstGlance]. <br>
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| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BY2:[3-[(1~{R})-1-(dimethylamino)ethyl]-4-oxidanyl-phenyl]+~{N}-ethyl-~{N}-methyl-carbamate'>BY2</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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| - | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BXT:'>BXT</scene></td></tr>
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| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BCHE, CHE1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cholinesterase Cholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.8 3.1.1.8] </span></td></tr>
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eul OCA], [http://pdbe.org/6eul PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eul RCSB], [http://www.ebi.ac.uk/pdbsum/6eul PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eul ProSAT]</span></td></tr>
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| - | </table>
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| - | == Disease ==
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| - | [[http://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:[http://omim.org/entry/177400 177400]]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait.
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| - | == Function ==
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| - | [[http://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN]] Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.<ref>PMID:19542320</ref> <ref>PMID:19452557</ref>
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| - | == References ==
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| - | <references/>
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Cholinesterase]]
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| - | [[Category: Human]]
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| - | [[Category: Large Structures]]
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| - | [[Category: Brazzolotto, X]]
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| - | [[Category: Dighe, S]]
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| - | [[Category: Mora, E De la]]
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| - | [[Category: Ross, B]]
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| - | [[Category: Alzheimer disease]]
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| - | [[Category: Butyrylcholinesterase]]
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| - | [[Category: Carbamylated]]
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| - | [[Category: Hydrolase]]
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| - | [[Category: Organophosphate]]
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| - | [[Category: Rational design]]
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| - | [[Category: Rivastigmine analogue]]
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