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4xo2

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Revision as of 17:45, 26 April 2023

crystal structure of GnsA from E.coli

Structural highlights

4xo2 is a 2 chain structure with sequence from Escherichia coli K-12. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GNSA_ECOLI Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation.^[1]

Publication Abstract from PubMed

Escherichia Coli GnsA is a regulator of phosphatidylethanolamine synthesis and functions as a suppressor of both a secG null mutation and fabA6 mutations. GnsA may also be a toxin with the cognate antitoxin YmcE. Here we report the crystal structure of GnsA to 1.8 A. GnsA forms a V shaped hairpin structure that is tightly associated into a homodimer. Our comprehensive structural study suggests that GnsA is structurally similar to an outer membrane protein, suggesting a function of protein binding.

Crystal structure of GnsA from Escherichia coli.,Wei Y, Zhan L, Gao Z, Prive GG, Dong Y Biochem Biophys Res Commun. 2015 Jun 19;462(1):1-7. doi:, 10.1016/j.bbrc.2015.03.133. Epub 2015 Apr 1. PMID:25839658^[2]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Sugai R, Shimizu H, Nishiyama K, Tokuda H. Overexpression of yccL (gnsA) and ydfY (gnsB) increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation of Escherichia coli. J Bacteriol. 2001 Oct;183(19):5523-8. PMID:11544213 doi:http://dx.doi.org/10.1128/JB.183.19.5523-5528.2001
↑ Wei Y, Zhan L, Gao Z, Prive GG, Dong Y. Crystal structure of GnsA from Escherichia coli. Biochem Biophys Res Commun. 2015 Jun 19;462(1):1-7. doi:, 10.1016/j.bbrc.2015.03.133. Epub 2015 Apr 1. PMID:25839658 doi:http://dx.doi.org/10.1016/j.bbrc.2015.03.133

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4xo2"

@@ Line 3: / Line 3: @@
 <StructureSection load='4xo2' size='340' side='right'caption='[[4xo2]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4xo2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XO2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XO2 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4xo2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XO2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XO2 FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4xo1|4xo1]]</td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xo2 OCA], [https://pdbe.org/4xo2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xo2 RCSB], [https://www.ebi.ac.uk/pdbsum/4xo2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xo2 ProSAT]</span></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">gnsA, yccL, b4517, JW0976 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xo2 OCA], [http://pdbe.org/4xo2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xo2 RCSB], [http://www.ebi.ac.uk/pdbsum/4xo2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xo2 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/GNSA_ECOLI GNSA_ECOLI]] Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation.<ref>PMID:11544213</ref>
+[https://www.uniprot.org/uniprot/GNSA_ECOLI GNSA_ECOLI] Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation.<ref>PMID:11544213</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 23: / Line 21: @@
 __TOC__
 </StructureSection>
-[[Category: Ecoli]]
+[[Category: Escherichia coli K-12]]
 [[Category: Large Structures]]
-[[Category: Dong, Y H]]
+[[Category: Dong YH]]
-[[Category: Gao, Z Q]]
+[[Category: Gao ZQ]]
-[[Category: Wei, Y]]
+[[Category: Wei Y]]
-[[Category: Zhan, L H]]
+[[Category: Zhan LH]]
-[[Category: Protein binding]]
-[[Category: Suppressor]]

4xo2

From Proteopedia

Revision as of 17:45, 26 April 2023

crystal structure of GnsA from E.coli

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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