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Deaminase
From Proteopedia
(Difference between revisions)
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</StructureSection> | </StructureSection> | ||
| - | == 3D Structures of deaminase == | ||
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| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *Cytidine deaminase | ||
| - | |||
| - | **[[1r5t]] – yCDA - yeast <BR /> | ||
| - | **[[2a8n]] – AtCDA – ''Agrobacterium tumefaciens'' <BR /> | ||
| - | **[[2g84]] – NeCDA – ''Nitrosomonas europaea'' <BR /> | ||
| - | **[[2d30]] – CDA – ''Bacillus anthracis'' <BR /> | ||
| - | **[[3dmo]] – CDA – ''Burkholderia pseudomallei'' <BR /> | ||
| - | **[[3ijf]] – MtCDA – ''Mycobacterium tuberculosis'' <BR /> | ||
| - | **[[4wif]], [[4wig]] – MtCDA (mutant) <BR /> | ||
| - | **[[3mpz]] – CDA – ''Mycobacterium smegmatis'' <BR /> | ||
| - | **[[3r2n]] – CDA – ''Mycobacterium leprae'' <BR /> | ||
| - | **[[4f3w]] – CDA – ''Mycobacterium marinum'' <BR /> | ||
| - | |||
| - | *''Cytidine deaminase complex with nucleoside'' | ||
| - | |||
| - | **[[1ctt]] – EcCDA + dihydro-pyrimidinone – ''Escherichia coli'' <BR /> | ||
| - | **[[1ctu]] – EcCDA + hydroxyl-dihydro-zebularine <BR /> | ||
| - | **[[1af2]] – EcCDA + uridine <BR /> | ||
| - | **[[1aln]] – EcCDA + deazacytidine <BR /> | ||
| - | **[[1jtk]] – BsCDA + tetrahydrodeoxyuridine - ''Bacillus subtilis'' <BR /> | ||
| - | **[[1uwz]], [[1ux0]], [[1ux1]] – BsCDA (mutant) + tetrahydrodeoxyuridine <BR /> | ||
| - | **[[1mq0]] – hCDA + β-ribofuranosyl diazepinone - human <BR /> | ||
| - | **[[1zab]] – mCDA + deazauridine - mouse <BR /> | ||
| - | **[[2fr5]] – mCDA + tetrahydrouridine <BR /> | ||
| - | **[[2fr6]] – mCDA + cytidine + uridine <BR /> | ||
| - | **[[4eg2]] – CDA + uridine - ''Vibrio cholerae'' <BR /> | ||
| - | |||
| - | *Cytosine deaminase | ||
| - | |||
| - | **[[1k6w]] – EcCDDA <BR /> | ||
| - | **[[1r9x]], [[1r9y]], [[1r9z]], [[1ra0]], [[1ra5]], [[3g77]] – EcCDDA (mutant)<BR /> | ||
| - | **[[1rb7]], [[1uaq]] – yCDDA <BR /> | ||
| - | **[[1ysb]], [[1ysd]] – yCDDA (mutant)<BR /> | ||
| - | |||
| - | *''Cytosine deaminase complex'' | ||
| - | |||
| - | **[[3r0d]] – EcCDDA + Zn <BR /> | ||
| - | **[[3rn6]] – EcCDDA + Zn + iso-guanine<BR /> | ||
| - | **[[1k70]] – EcCDDA + pyrimidine derivative<BR /> | ||
| - | **[[1rak]] – EcCDDA (mutant) + pyrimidine derivative<BR /> | ||
| - | **[[3o7u]] – EcCDDA + Zn + phosphono-cytosine<BR /> | ||
| - | **[[1ox7]] – yCDDA + Zn <BR /> | ||
| - | **[[1p6o]] – yCDDA + pyrimidine derivative<BR /> | ||
| - | **[[2o3k]] – yCDDA (mutant) + pyrimidine derivative<BR /> | ||
| - | **[[4r7w]], [[4r85]], [[4r88]] – KpCDDA + cytosine derivative – ''Klebsiella pneumoniae''<BR /> | ||
| - | |||
| - | * Deoxycytidylate deaminase | ||
| - | |||
| - | **[[2hvv]], [[2hvw]] – SmDCMP - ''Streptococcus mutans'' <BR /> | ||
| - | **[[1vq2]] – DCMP - Enterobacteria phage T4 <BR /> | ||
| - | **[[4p9c]] – CyDCMP + deoxyCMP - Cyanophage S-TIM5 <BR /> | ||
| - | **[[4p9d]] – CyDCMP + TMP <BR /> | ||
| - | **[[4p9e]] – CyDCMP <BR /> | ||
| - | **[[2w4l]] – hDCMP<BR /> | ||
| - | **[[5jfy]] – DCMP - cabbage<BR /> | ||
| - | |||
| - | *Guanine deaminase | ||
| - | |||
| - | **[[1tiy]], [[1wkq]] – BsGDA <BR /> | ||
| - | **[[3e0l]] – hGDA<br /> | ||
| - | |||
| - | *''Guanine deaminase complex with nucleoside'' | ||
| - | |||
| - | **[[2i9u]] – GDA + guanine – ''Clostridium acetobutylicum'' <BR /> | ||
| - | **[[2ood]] – GDA + guanine – ''Bradrhizobium japonicum'' <BR /> | ||
| - | **[[4lc5]], [[4lcn]], [[4hrq]] – NeGDA + guanine derivative<BR /> | ||
| - | **[[4hrw]] – NeGDA (mutant) + guanine derivative<BR /> | ||
| - | **[[4lco]] – NeGDA + ameline<BR /> | ||
| - | **[[4lcp]] – NeGDA + diaminopurine<BR /> | ||
| - | **[[4ld2]] – NeGDA + cytidine<BR /> | ||
| - | **[[4ld4]] – NeGDA + cytosine<BR /> | ||
| - | **[[2uz9]] – hGDA + xanthine <BR /> | ||
| - | **[[4aql]] – hGDA + valacyclovir <BR /> | ||
| - | |||
| - | *Adenine deaminase | ||
| - | |||
| - | **[[2ics]] – ADA - ''Enterococcus faecalis''<BR /> | ||
| - | **[[3nqb]], [[3t81]], [[3t8l]] – AtADA <BR /> | ||
| - | |||
| - | *Adenosine deaminase See [[Adenosine deaminase]] | ||
| - | |||
| - | *Glucosamine 6-phosphate deaminase | ||
| - | |||
| - | **[[1dea]], [[1cd5]], [[1fs6]], [[1fsf]] – EcGPD <BR /> | ||
| - | **[[1jt9]] – EcGPD (mutant) <BR /> | ||
| - | **[[2ri0]] – SmGPD – ''Streptococcus mutans'' <BR /> | ||
| - | **[[6nbg]] – KpGPD <BR /> | ||
| - | **[[3hn6]] – GPD – ''Borrelia burgdorferi''<br /> | ||
| - | **[[1j5x]] – GPD – ''Thermotoga maritima''<br /> | ||
| - | **[[2bkv]] – BsGPD <br /> | ||
| - | **[[2bkx]] – BsGPD + fructose 6-phosphate<BR /> | ||
| - | **[[4r7t]] – VcGPD <br /> | ||
| - | **[[5hj5]] – VcGPD + fructose 6-phosphate + glucose-6-phosphate<BR /> | ||
| - | **[[1hor]] – EcGPD + deoxy-amino glucitol-phosphate<BR /> | ||
| - | **[[1hot]], [[1frz]], [[1fs5]], [[2wu1]] – EcGPD + N-acetyl-glucosamine-6-phosphate<BR /> | ||
| - | **[[1fqo]] – EcGPD + fructose 6-phosphate<BR /> | ||
| - | **[[2ri1]] – SmGPD + glucosamine-6-phosphate<BR /> | ||
| - | |||
| - | *1-aminocyclopropane-1-carboxylate (ACC) deaminase | ||
| - | |||
| - | **[[1f2d]] – WsACCD + PLP – ''Williopsis saturnus''<BR /> | ||
| - | **[[1j0c]] – WsACCD (mutant) + PLP <BR /> | ||
| - | **[[1j0d]] – WsACCD (mutant) + inhibitor<BR /> | ||
| - | **[[1j0e]] – WsACCD (mutant) + PLP + ACC<BR /> | ||
| - | **[[1j0a]] – PhACCD + PLP + 2-propanol – ''Pyrococcus horikoshii''<BR /> | ||
| - | **[[1j0b]] – PhACCD + inhibitor<BR /> | ||
| - | **[[1tyz]] – PsACCD + PLP - ''Pseudomonas''<BR /> | ||
| - | **[[1rqx]] – PsACCD + PLP + inhibitor <BR /> | ||
| - | **[[1tz2]] – PsACCD + PLP + ACC<BR /> | ||
| - | **[[1tzj]] – PsACCD + PLP + vinylglycine<BR /> | ||
| - | **[[1tzk]] – PsACCD + PLP + α-ketobutyrate<BR /> | ||
| - | **[[1tzm]] – PsACCD + PLP + chloroalanine<BR /> | ||
| - | |||
| - | *dCTP deaminase | ||
| - | |||
| - | **[[2qlp]] – MtCTPD <BR /> | ||
| - | **[[3km3]] – CTPD – ''Anaplasma phagocytophilum''<br /> | ||
| - | **[[4dhk]] – CTPD - ''Burkholderia thailandensis''<BR /> | ||
| - | |||
| - | *''dCTP deaminase complex'' | ||
| - | |||
| - | **[[1xs1]] – EcCTPD + dUTP<BR /> | ||
| - | **[[1xs4]] – EcCTPD (mutant) + dCTP<BR /> | ||
| - | **[[2j4h]] – EcCTPD (mutant) + dCDP<BR /> | ||
| - | **[[1xs6]], [[2v9x]] – EcCTPD (mutant) + dUTP<BR /> | ||
| - | **[[2j4q]] – EcCTPD (mutant) + dTTP + dTDP<BR /> | ||
| - | **[[2qxx]] – MtCTPD + dTTP<BR /> | ||
| - | |||
| - | *dCTP deaminase-dUTPase | ||
| - | |||
| - | **[[2hxb]], [[1ogh]], [[1pkh]], [[3gf0]] – MjDCD-DUT – ''Methanocaldococcus jannaschii'' <BR /> | ||
| - | **[[1pkj]] – MjDCD-DUT + dUTP<BR /> | ||
| - | **[[2hxd]] – MjDCD-DUT (mutant) + dUTP derivative<BR /> | ||
| - | **[[1pkk]] – MjDCD-DUT + dCTP<BR /> | ||
| - | **[[4xjc]] – DCD-DUT + TTP – ''Bacillus halodurans''<BR /> | ||
| - | **[[4a6a]] – MtDCD-DUT (mutant) + TTP <BR /> | ||
| - | |||
| - | *Porphobilinogen deaminase See [[Porphobilinogen Deaminase]] | ||
| - | |||
| - | *Blasticidin-S deaminase | ||
| - | |||
| - | **[[1wn5]], [[2z3g]] – AtBSD – ''Aspergillus terreus'' <BR /> | ||
| - | **[[2z3j]] – AtBSD (mutant) <BR /> | ||
| - | **[[3oj6]] – BSD – Coccidioides immitis <BR /> | ||
| - | **[[1wn6]] – AtBSD + blasticidin-S intermediate<BR /> | ||
| - | **[[2z3h]] – AtBSD + deaminohydroxy blasticidin-S <BR /> | ||
| - | **[[2z3i]] – AtBSD (mutant) + blasticidin-S <BR /> | ||
| - | |||
| - | *Threonine deaminase | ||
| - | |||
| - | **[[1tdj]] – EcTHD + PLP <BR /> | ||
| - | **[[2gn0]], [[2gn1]] – StTHD + PLP derivative – ''Salmonella typhimurium''<BR /> | ||
| - | **[[2gn2]] – StTHD + PLP derivative + CMP<BR /> | ||
| - | **[[3iau]] – THD + PLP derivative – tomato<BR /> | ||
| - | **[[1ve5]] – THD + PLP – ''Thermus thermophilus''<BR /> | ||
| - | |||
| - | *L-serine deaminase | ||
| - | |||
| - | **[[1pwe]] – rLSD - rat <BR /> | ||
| - | **[[1p5j]], [[2rkb]] – hLSD (mutant) + PLP <BR /> | ||
| - | **[[1pwh]] – rLSD + PLP derivative <BR /> | ||
| - | |||
| - | *D-serine deaminase | ||
| - | |||
| - | **[[3r0x]], [[3r0z]] – DSD – ''Salmonella enterica''<BR /> | ||
| - | **[[3ss7]], [[3ss9]] – EcDSD + PLP <BR /> | ||
| - | **[[3gwq]] – DSD - ''Burkholderia xenovorans''<BR /> | ||
| - | |||
| - | *L-amino acid deaminase | ||
| - | |||
| - | **[[5fjm]] – PmLSD – ''Proteus myxofaciens'' <BR /> | ||
| - | **[[5fjn]] – PmLSD + anthranilate <BR /> | ||
| - | **[[5i39]], [[5hxw]] – LSD + FAD – ''Proteus vulgaris'' <BR /> | ||
| - | |||
| - | *2-aminomuconate deaminase | ||
| - | |||
| - | **[[6izh]] – PsAMD – <BR /> | ||
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| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:22, 4 June 2019
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References
- ↑ Bransteitter R, Pham P, Scharff MD, Goodman MF. Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase. Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4102-7. Epub 2003 Mar 21. PMID:12651944 doi:http://dx.doi.org/10.1073/pnas.0730835100
- ↑ Egeblad L, Welin M, Flodin S, Graslund S, Wang L, Balzarini J, Eriksson S, Nordlund P. Pan-Pathway Based Interaction Profiling of FDA-Approved Nucleoside and Nucleobase Analogs with Enzymes of the Human Nucleotide Metabolism. PLoS One. 2012;7(5):e37724. Epub 2012 May 25. PMID:22662200 doi:10.1371/journal.pone.0037724
- ↑ Negroni L, Samson M, Guigonis JM, Rossi B, Pierrefite-Carle V, Baudoin C. Treatment of colon cancer cells using the cytosine deaminase/5-fluorocytosine suicide system induces apoptosis, modulation of the proteome, and Hsp90beta phosphorylation. Mol Cancer Ther. 2007 Oct;6(10):2747-56. PMID:17938268 doi:http://dx.doi.org/10.1158/1535-7163.MCT-07-0040
- ↑ Ireton GC, Black ME, Stoddard BL. The 1.14 A crystal structure of yeast cytosine deaminase: evolution of nucleotide salvage enzymes and implications for genetic chemotherapy. Structure. 2003 Aug;11(8):961-72. PMID:12906827
