Dehydroquinase
From Proteopedia
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</StructureSection> | </StructureSection> | ||
| - | ==3D structures of dehydroquinase== | ||
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| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *DHQD-I | ||
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| - | **[[1qfe]], [[1gqn]], [[3l2i]], [[3oex]], [[4gfs]], [[4cnn]] – StDHQD – ''Salmonella typhi'' <br /> | ||
| - | **[[3o1n]], [[4guf]] – StDHQD (mutant) <br /> | ||
| - | **[[1sfl]] – SaDHQD – ''Staphylococcus aureus''<br /> | ||
| - | **[[2ocz]] – DHQD – ''Streptococcus pyrogenes''<br /> | ||
| - | **[[2egz]], [[2ysw]] – DHQD – ''Aquifex aeolicus''<br /> | ||
| - | **[[2yr1]] – DHQD – ''Geobacillus kaustophilus''<br /> | ||
| - | **[[2ox1]] – DHQD – ''Archaeoglobus fulgidus''<br /> | ||
| - | **[[3l9c]] – DHQD – ''Streptococcus mutans''<br /> | ||
| - | **[[4ph6]] – DHQD – ''Enterococcus faecalis''<br /> | ||
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| - | *DHQD-I complexes | ||
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| - | **[[1l9w]] – StDHQD + amino-dehydroxy-cyclohex-enecarboxylate <br /> | ||
| - | **[[1sfj]] – SaDHQD + dehydroquinic acid <br /> | ||
| - | **[[3js3]] – CdDHQD + amino-dehydroxy-cyclohex-enecarboxylate – ''Clostridium difficile''<br /> | ||
| - | **[[3lb0]] – StDHQD + citrate<br /> | ||
| - | **[[3s42]] – StDHQD + borate + malonate<br /> | ||
| - | **[[3m7w]] – StDHQD + dehydroquinic acid <br /> | ||
| - | **[[4gui]] – StDHQD + quinic acid <br /> | ||
| - | **[[4iuo]] – StDHQD (mutant) + quinic acid <br /> | ||
| - | **[[3nnt]] – StDHQD (mutant) + dehydroquinic acid <br /> | ||
| - | **[[4gug]], [[4guh]] – StDHQD (mutant) + dehydroshikimate<br /> | ||
| - | **[[4guj]] – StDHQD + shikimate<br /> | ||
| - | **[[4clm]], [[4cno]], [[4cnp]] – StDHQD + inhibitor<br /> | ||
| - | **[[4h3d]] – CdDHQD + comenic acid <br /> | ||
| - | **[[4uio]] – DHQD + dehydroquinic acid derivative – ''Salmonella enterica''<br /> | ||
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| - | *DHQD-II or 3-dehydroquinate dehydratase | ||
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| - | **[[1d0i]], [[1gu0]] – ScDHQD – ''Streptomyces coelicolor'' <br /> | ||
| - | **[[2dhq]], [[1h05]] – MtDHQD – ''Mycobacterium tuberculosis'' <br /> | ||
| - | **[[4ckw]], [[4ckx]], [[4ckz]] – MtDHQD (mutant) <br /> | ||
| - | **[[1gqo]] – DHQD – ''Bacillus subtilis'' <br /> | ||
| - | **[[1uqr]] – DHQD – ''Actinobacillus pleuropneumoniae''<br /> | ||
| - | **[[2uyg]] – DHQD – ''Thermus thermoophilus''<br /> | ||
| - | **[[3lwz]] – DHQD – ''Yersinia pestis''<br /> | ||
| - | **[[3kip]] – DHQD – ''Candida albicans''<br /> | ||
| - | **[[3u80]] – DHQD – ''Bifidobacterium longum'' <br /> | ||
| - | **[[4l8l]] – DHQD – ''Pseudomonas aeruginosa'' <br /> | ||
| - | **[[4rc9]], [[4rhc]], [[4zc1]], [[5b6p]], [[5wrf]], [[5x47]], [[5yhm]], [[5yl5]], [[5ypq]] – AbDHQD – ''Acinetobacter baumannii''<br /> | ||
| - | **[[6cv6]] – DHQD – ''Paraburkholderia phymatum''<br /> | ||
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| - | *DHQD-II complexes | ||
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| - | **[[1gu1]] – ScDHQD + anhydroquinic acid<br /> | ||
| - | **[[1v1j]] – ScDHQD + anhydrofluoroquinic acid<br /> | ||
| - | **[[2bt4]], [[2cjf]] – ScDHQD + inhibitor<br /> | ||
| - | **[[1gtz]] – ScDHQD (mutant) + dehydroshikimate<br /> | ||
| - | **[[1j2y]] – HpDHQD + dehydroquinic acid – ''Helicobacter pylori''<br /> | ||
| - | **[[1h0s]] – MtDHQD + hydroxyl-imino-quinic acid<br /> | ||
| - | **[[1h0r]] – MtDHQD + anhydroquinic acid<br /> | ||
| - | **[[2c4v]] – HpDHQD + citrate<br /> | ||
| - | **[[2c4w]], [[2c57]], [[2wks]], [[2xb9]], [[2xd9]], [[2xda]], [[4b6r]], [[4b6s]] – HpDHQD + inhibitor<br /> | ||
| - | **[[3n59]] – MtDHQD + dehydroshikimate<br /> | ||
| - | **[[3n8k]] – MtDHQD + citrazinic acid<br /> | ||
| - | **[[2xb8]], [[3n76]], [[3n7a]], [[3n86]], [[3n87]], [[3n8n]], [[2y71]], [[2y76]], [[2y77]], [[4b6o]], [[4b6p]], [[4b6q]], [[4civ]], [[4cix]], [[4ciw]], [[4ciy]], [[4ki7]], [[4kij]], [[4kiu]], [[4kiw]] – MtDHQD + inhibitor<br /> | ||
| - | **[[4cky]], [[4cl0]] – MtDHQD + dehydroquinic acid derivative<br /> | ||
| - | **[[4v0s]] – MtDHQD (mutant) + dehydroquinic acid derivative<br /> | ||
| - | **[[5ydb]] – AbDHQD + dehydroquinic acid derivative<br /> | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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References
- ↑ Herrmann KM. The Shikimate Pathway: Early Steps in the Biosynthesis of Aromatic Compounds. Plant Cell. 1995 Jul;7(7):907-919. PMID:12242393 doi:http://dx.doi.org/10.1105/tpc.7.7.907
- ↑ Dias MV, Snee WC, Bromfield KM, Payne R, Palaninathan SK, Ciulli A, Howard NI, Abell C, Sacchettini JC, Blundell TL. Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis. Biochem J. 2011 Mar 17. PMID:21410435 doi:10.1042/BJ20110002
- ↑ Light SH, Antanasijevic A, Krishna SN, Caffrey M, Anderson WF, Lavie A. Crystal structures of type I dehydroquinate dehydratase in complex with quinate and shikimate suggest a novel mechanism of Schiff base formation. Biochemistry. 2014 Feb 11;53(5):872-80. doi: 10.1021/bi4015506. Epub 2014 Jan 31. PMID:24437575 doi:http://dx.doi.org/10.1021/bi4015506
