6p2r

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'''Unreleased structure'''
 
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The entry 6p2r is ON HOLD until Paper Publication
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==Structure of S. cerevisiae protein O-mannosyltransferase Pmt1-Pmt2 complex bound to the sugar donor==
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<StructureSection load='6p2r' size='340' side='right'caption='[[6p2r]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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Authors: Bai, L., Li, H.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6p2r]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P2R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6P2R FirstGlance]. <br>
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Description: Structure of S. cerevisiae protein O-mannosyltransferase Pmt1-Pmt2 complex bound to the sugar donor
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPL:1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>CPL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NNM:(3R)-3,31-dimethyl-7,11,15,19,23,27-hexamethylidenedotriacont-31-en-1-yl+dihydrogen+phosphate'>NNM</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dolichyl-phosphate-mannose--protein_mannosyltransferase Dolichyl-phosphate-mannose--protein mannosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.109 2.4.1.109] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6p2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p2r OCA], [http://pdbe.org/6p2r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6p2r RCSB], [http://www.ebi.ac.uk/pdbsum/6p2r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6p2r ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/PMT1_YEAST PMT1_YEAST]] Protein O-mannosyltransferase involved in O-glycosylation which is essential for cell wall rigidity. Forms a heterodimeric complex with PMT2 and more rarely with PMT3 to transfer mannose from Dol-P-mannose to Ser or Thr residues on proteins. The PMT1-PMT2 complex participates in oxidative protein folding, ER-associated protein degradation (ERAD), as well as ER export. Required for incorporation of proteins in the cell wall.<ref>PMID:10764776</ref> <ref>PMID:18182384</ref> <ref>PMID:8367478</ref> <ref>PMID:8543034</ref> <ref>PMID:9466258</ref> [[http://www.uniprot.org/uniprot/PMT2_YEAST PMT2_YEAST]] Protein O-mannosyltransferase involved in O-glycosylation which is essential for cell wall rigidity. Forms a heterodimeric complex with PMT2 and more rarely with PMT5 to transfer mannose from Dol-P-mannose to Ser or Thr residues on proteins. The PMT1-PMT2 complex participates in oxidative protein folding, ER-associated protein degradation (ERAD), as well as ER export.<ref>PMID:15377669</ref> <ref>PMID:18182384</ref> <ref>PMID:21147851</ref> <ref>PMID:8543034</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Dolichyl-phosphate-mannose--protein mannosyltransferase]]
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[[Category: Large Structures]]
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[[Category: Bai, L]]
[[Category: Li, H]]
[[Category: Li, H]]
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[[Category: Bai, L]]
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[[Category: Complex]]
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[[Category: Glycosylation]]
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[[Category: Transferase]]

Revision as of 05:53, 10 July 2019

Structure of S. cerevisiae protein O-mannosyltransferase Pmt1-Pmt2 complex bound to the sugar donor

PDB ID 6p2r

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