|
|
| Line 3: |
Line 3: |
| | <StructureSection load='6bnm' size='340' side='right'caption='[[6bnm]], [[Resolution|resolution]] 1.90Å' scene=''> | | <StructureSection load='6bnm' size='340' side='right'caption='[[6bnm]], [[Resolution|resolution]] 1.90Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[6bnm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BNM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BNM FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6bnm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BNM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BNM FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PREX2, DEPDC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bnm OCA], [http://pdbe.org/6bnm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bnm RCSB], [http://www.ebi.ac.uk/pdbsum/6bnm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bnm ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bnm OCA], [https://pdbe.org/6bnm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bnm RCSB], [https://www.ebi.ac.uk/pdbsum/6bnm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bnm ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/PREX2_HUMAN PREX2_HUMAN]] Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase.<ref>PMID:15304342</ref> <ref>PMID:15304343</ref> <ref>PMID:15897194</ref> | + | [https://www.uniprot.org/uniprot/PREX2_HUMAN PREX2_HUMAN] Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase.<ref>PMID:15304342</ref> <ref>PMID:15304343</ref> <ref>PMID:15897194</ref> |
| | == References == | | == References == |
| | <references/> | | <references/> |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Human]] | + | [[Category: Homo sapiens]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Cash, J N]] | + | [[Category: Cash JN]] |
| - | [[Category: Sharma, P V]] | + | [[Category: Sharma PV]] |
| - | [[Category: Tesmer, J J.G]] | + | [[Category: Tesmer JJG]] |
| - | [[Category: Beta sandwich]]
| + | |
| - | [[Category: Lipid binding protein]]
| + | |
| - | [[Category: Phosphatidylinositol-binding]]
| + | |
| - | [[Category: Pleckstrin homology domain]]
| + | |
| Structural highlights
Function
PREX2_HUMAN Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase.[1] [2] [3]
References
- ↑ Rosenfeldt H, Vazquez-Prado J, Gutkind JS. P-REX2, a novel PI-3-kinase sensitive Rac exchange factor. FEBS Lett. 2004 Aug 13;572(1-3):167-71. PMID:15304342 doi:http://dx.doi.org/10.1016/j.febslet.2004.06.097
- ↑ Donald S, Hill K, Lecureuil C, Barnouin R, Krugmann S, John Coadwell W, Andrews SR, Walker SA, Hawkins PT, Stephens LR, Welch HC. P-Rex2, a new guanine-nucleotide exchange factor for Rac. FEBS Lett. 2004 Aug 13;572(1-3):172-6. doi: 10.1016/j.febslet.2004.06.096. PMID:15304343 doi:http://dx.doi.org/10.1016/j.febslet.2004.06.096
- ↑ Joseph RE, Norris FA. Substrate specificity and recognition is conferred by the pleckstrin homology domain of the Dbl family guanine nucleotide exchange factor P-Rex2. J Biol Chem. 2005 Jul 29;280(30):27508-12. Epub 2005 May 16. PMID:15897194 doi:http://dx.doi.org/M412495200
|
