4xuw

From Proteopedia

(Difference between revisions)

Revision as of 17:53, 26 April 2023

Structure of the hazelnut allergen, Cor a 8

Structural highlights

4xuw is a 2 chain structure with sequence from Corylus avellana. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

NLTP_CORAV Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes. May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues.[RuleBase:RU000628]

Publication Abstract from PubMed

Nonspecific lipid transfer proteins (nsLTPs) are basic proteins, stabilized by four disulfide bonds, and are expressed throughout the plant kingdom. These proteins are also known as important allergens in fruits and tree nuts. In this study, the nsLTP from hazelnuts, Cor a 8, was purified and its crystal structure determined. The protein is stable at low pH and refolds after thermal denaturation. Molecular dynamics simulations were used to provide an insight into conformational changes of Cor a 8 upon ligand binding. When known epitope areas from Pru p 3 were compared to those of Cor a 8, differences were obvious, which may contribute to limited cross-reactivity between peach and hazelnut allergens. Differences in epitope regions may contribute to limited cross-reactivity between Cor a 8 and nsLTPs from other plant sources. The structure of Cor a 8 represents the first resolved structure of a hazelnut allergen.

Structural and Functional Characterization of the Hazelnut Allergen Cor a 8.,Offermann LR, Bublin M, Perdue ML, Pfeifer S, Dubiela P, Borowski T, Chruszcz M, Hoffmann-Sommergruber K J Agric Food Chem. 2015 Oct 7. PMID:26417906^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Offermann LR, Bublin M, Perdue ML, Pfeifer S, Dubiela P, Borowski T, Chruszcz M, Hoffmann-Sommergruber K. Structural and Functional Characterization of the Hazelnut Allergen Cor a 8. J Agric Food Chem. 2015 Oct 7. PMID:26417906 doi:http://dx.doi.org/10.1021/acs.jafc.5b03534

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4xuw"

@@ Line 3: / Line 3: @@
 <StructureSection load='4xuw' size='340' side='right'caption='[[4xuw]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4xuw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Corylus_avellana Corylus avellana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XUW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XUW FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4xuw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Corylus_avellana Corylus avellana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XUW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XUW FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xuw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xuw OCA], [http://pdbe.org/4xuw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xuw RCSB], [http://www.ebi.ac.uk/pdbsum/4xuw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xuw ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xuw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xuw OCA], [https://pdbe.org/4xuw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xuw RCSB], [https://www.ebi.ac.uk/pdbsum/4xuw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xuw ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/Q9ATH2_CORAV Q9ATH2_CORAV]] Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes. May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues.[RuleBase:RU000628]
+[https://www.uniprot.org/uniprot/NLTP_CORAV NLTP_CORAV] Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes. May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues.[RuleBase:RU000628]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 24: / Line 24: @@
 [[Category: Corylus avellana]]
 [[Category: Large Structures]]
-[[Category: Bublin, M]]
+[[Category: Bublin M]]
-[[Category: Chruszcz, M]]
+[[Category: Chruszcz M]]
-[[Category: Dubiela, P]]
+[[Category: Dubiela P]]
-[[Category: Hoffmann-Sommergruber, K]]
+[[Category: Hoffmann-Sommergruber K]]
-[[Category: Offermann, L R]]
+[[Category: Offermann LR]]
-[[Category: Perdue, M L]]
+[[Category: Perdue ML]]
-[[Category: Pfeifer, S]]
+[[Category: Pfeifer S]]
-[[Category: Allergen]]
-[[Category: Plant protein]]

4xuw

From Proteopedia

Revision as of 17:53, 26 April 2023

Structure of the hazelnut allergen, Cor a 8

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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