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6in1
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the first bromodomain of BRD4 in complex with 18-Crown-6== | |
| - | + | <StructureSection load='6in1' size='340' side='right'caption='[[6in1]], [[Resolution|resolution]] 1.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6in1]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IN1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IN1 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LOC:N-[(7S)-1,2,3,10-TETRAMETHOXY-9-OXO-6,7-DIHYDRO-5H-BENZO[D]HEPTALEN-7-YL]ETHANAMIDE'>LOC</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=O4B:1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE'>O4B</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6in1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6in1 OCA], [http://pdbe.org/6in1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6in1 RCSB], [http://www.ebi.ac.uk/pdbsum/6in1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6in1 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Kitakami, R]] | ||
| + | [[Category: Kosaka, Y]] | ||
| + | [[Category: Matsumoto, K]] | ||
| + | [[Category: Mizuguchi, M]] | ||
| + | [[Category: Nabeshima, Y]] | ||
| + | [[Category: Yokoyama, T]] | ||
| + | [[Category: Bromodomain-containing protein 4]] | ||
| + | [[Category: Transcription]] | ||
Revision as of 08:59, 30 October 2019
Crystal structure of the first bromodomain of BRD4 in complex with 18-Crown-6
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