6rvy

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m (Protected "6rvy" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6rvy is ON HOLD until Paper Publication
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==Inward-open structure of the ASCT2 (SLC1A5) mutant C467R in absence of substrate==
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<StructureSection load='6rvy' size='340' side='right'caption='[[6rvy]], [[Resolution|resolution]] 4.13&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6rvy]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RVY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RVY FirstGlance]. <br>
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Description:
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6rvx|6rvx]]</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rvy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rvy OCA], [http://pdbe.org/6rvy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rvy RCSB], [http://www.ebi.ac.uk/pdbsum/6rvy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rvy ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/AAAT_HUMAN AAAT_HUMAN]] Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids (PubMed:8702519). Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904).<ref>PMID:10708449</ref> <ref>PMID:23492904</ref> <ref>PMID:8702519</ref> (Microbial infection) Acts as a cell surface receptor for Feline endogenous virus RD114.<ref>PMID:10051606</ref> <ref>PMID:10196349</ref> (Microbial infection) Acts as a cell surface receptor for Baboon M7 endogenous virus.<ref>PMID:10196349</ref> (Microbial infection) Acts as a cell surface receptor for type D simian retroviruses.<ref>PMID:10196349</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Garaeva, A A]]
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[[Category: Guskov, A]]
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[[Category: Paulino, C]]
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[[Category: Slotboom, D J]]
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[[Category: Membrane protein]]

Revision as of 06:06, 7 August 2019

Inward-open structure of the ASCT2 (SLC1A5) mutant C467R in absence of substrate

PDB ID 6rvy

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