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6dm6
From Proteopedia
(Difference between revisions)
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<StructureSection load='6dm6' size='340' side='right'caption='[[6dm6]], [[Resolution|resolution]] 2.25Å' scene=''> | <StructureSection load='6dm6' size='340' side='right'caption='[[6dm6]], [[Resolution|resolution]] 2.25Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6dm6]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DM6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DM6 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6dm6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Riccn Riccn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DM6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DM6 FirstGlance]. <br> |
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=MLU:N-METHYL-D-LEUCINE'>MLU</scene>, <scene name='pdbligand=MP8:(4R)-4-METHYL-L-PROLINE'>MP8</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=NZC:N-METHYLIDENE-L-THREONINE'>NZC</scene></td></tr> | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=MLU:N-METHYL-D-LEUCINE'>MLU</scene>, <scene name='pdbligand=MP8:(4R)-4-METHYL-L-PROLINE'>MP8</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=NZC:N-METHYLIDENE-L-THREONINE'>NZC</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dnaN, RC0583 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272944 RICCN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dm6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dm6 OCA], [http://pdbe.org/6dm6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dm6 RCSB], [http://www.ebi.ac.uk/pdbsum/6dm6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dm6 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dm6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dm6 OCA], [http://pdbe.org/6dm6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dm6 RCSB], [http://www.ebi.ac.uk/pdbsum/6dm6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dm6 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/DPO3B_RICCN DPO3B_RICCN]] Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.[UniProtKB:P0A988] | [[http://www.uniprot.org/uniprot/DPO3B_RICCN DPO3B_RICCN]] Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.[UniProtKB:P0A988] | ||
| + | |||
| + | ==See Also== | ||
| + | *[[DNA polymerase 3D structures|DNA polymerase 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| + | [[Category: Riccn]] | ||
[[Category: Structural genomic]] | [[Category: Structural genomic]] | ||
[[Category: Dna polymerase iii subunit beta]] | [[Category: Dna polymerase iii subunit beta]] | ||
Revision as of 12:29, 17 July 2019
Structure of DNA polymerase III subunit beta from Rickettsia conorii in complex with a natural product
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