6jbu

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'''Unreleased structure'''
 
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The entry 6jbu is ON HOLD until Paper Publication
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==High resolution crystal structure of human FLRT3 LRR domain in complex with mouse CIRL3 Olfactomedin like domain==
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<StructureSection load='6jbu' size='340' side='right'caption='[[6jbu]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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Authors: Liu, H., Li, Z., Xu, F.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6jbu]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JBU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JBU FirstGlance]. <br>
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Description: High resolution crystal structure of human FLRT3 LRR domain in complex with mouse CIRL3 Olfactomedin like domain
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jbu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jbu OCA], [http://pdbe.org/6jbu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jbu RCSB], [http://www.ebi.ac.uk/pdbsum/6jbu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jbu ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/FLRT3_HUMAN FLRT3_HUMAN]] Kallmann syndrome. The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. Some patients carrying mutations in FLRT3 also have a mutation in another HH-associated gene including FGFR1, HS6ST1 and FGF17 (PubMed:23643382).<ref>PMID:23643382</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/AGRL3_MOUSE AGRL3_MOUSE]] Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells (PubMed:22405201, PubMed:25728924, PubMed:26235031). Plays a role in the development of glutamatergic synapses in the cortex (PubMed:22405201, PubMed:24739570). Important in determining the connectivity rates between the principal neurons in the cortex (PubMed:24739570).<ref>PMID:22405201</ref> <ref>PMID:24739570</ref> <ref>PMID:25728924</ref> <ref>PMID:26235031</ref> [[http://www.uniprot.org/uniprot/FLRT3_HUMAN FLRT3_HUMAN]] May have a function in cell adhesion and/or receptor signaling.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Li, Z]]
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[[Category: Liu, H]]
[[Category: Xu, F]]
[[Category: Xu, F]]
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[[Category: Liu, H]]
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[[Category: Cell adhesion]]
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[[Category: Li, Z]]
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[[Category: Complex]]
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[[Category: Membrane glycoprotein]]

Revision as of 15:27, 29 January 2020

High resolution crystal structure of human FLRT3 LRR domain in complex with mouse CIRL3 Olfactomedin like domain

PDB ID 6jbu

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