3bwp

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{{STRUCTURE_3bwp| PDB=3bwp | SCENE= }}
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'''Crystal structure of a self-spliced group II intron'''
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===Crystal structure of a self-spliced group II intron===
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==Overview==
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Group II introns are self-splicing ribozymes that catalyze their own excision from precursor transcripts and insertion into new genetic locations. Here we report the crystal structure of an intact, self-spliced group II intron from Oceanobacillus iheyensis at 3.1 angstrom resolution. An extensive network of tertiary interactions facilitates the ordered packing of intron subdomains around a ribozyme core that includes catalytic domain V. The bulge of domain V adopts an unusual helical structure that is located adjacent to a major groove triple helix (catalytic triplex). The bulge and catalytic triplex jointly coordinate two divalent metal ions in a configuration that is consistent with a two-metal ion mechanism for catalysis. Structural and functional analogies support the hypothesis that group II introns and the spliceosome share a common ancestor.
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(as it appears on PubMed at http://www.pubmed.gov), where 18388288 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18388288}}
==About this Structure==
==About this Structure==
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[[Category: Ribonucleic acid]]
[[Category: Ribonucleic acid]]
[[Category: Rna]]
[[Category: Rna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:33:30 2008''

Revision as of 16:33, 28 July 2008

Image:3bwp.png

Template:STRUCTURE 3bwp

Crystal structure of a self-spliced group II intron

Template:ABSTRACT PUBMED 18388288

About this Structure

3BWP is a Single protein structure. Full crystallographic information is available from OCA.

Reference

Crystal structure of a self-spliced group II intron., Toor N, Keating KS, Taylor SD, Pyle AM, Science. 2008 Apr 4;320(5872):77-82. PMID:18388288

Page seeded by OCA on Mon Jul 28 19:33:30 2008

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