6gr2

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Current revision (05:16, 21 November 2024) (edit) (undo)
 
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<StructureSection load='6gr2' size='340' side='right'caption='[[6gr2]], [[Resolution|resolution]] 2.49&Aring;' scene=''>
<StructureSection load='6gr2' size='340' side='right'caption='[[6gr2]], [[Resolution|resolution]] 2.49&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6gr2]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GR2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GR2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6gr2]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GR2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6GR2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.49&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1wuu|1wuu]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Galactokinase Galactokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.6 2.7.1.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6gr2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gr2 OCA], [https://pdbe.org/6gr2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6gr2 RCSB], [https://www.ebi.ac.uk/pdbsum/6gr2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6gr2 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gr2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gr2 OCA], [http://pdbe.org/6gr2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gr2 RCSB], [http://www.ebi.ac.uk/pdbsum/6gr2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gr2 ProSAT]</span></td></tr>
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</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/GALK1_HUMAN GALK1_HUMAN]] Defects in GALK1 are the cause of galactosemia II (GALCT2) [MIM:[http://omim.org/entry/230200 230200]]. Galactosemia II is an autosomal recessive deficiency characterized by congenital cataracts during infancy and presenile cataracts in the adult population. The cataracts are secondary to accumulation of galactitol in the lenses.<ref>PMID:10521295</ref> <ref>PMID:10790206</ref> <ref>PMID:11231902</ref> <ref>PMID:11139256</ref> <ref>PMID:12694189</ref> <ref>PMID:15024738</ref>
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[https://www.uniprot.org/uniprot/GALK1_HUMAN GALK1_HUMAN] Defects in GALK1 are the cause of galactosemia II (GALCT2) [MIM:[https://omim.org/entry/230200 230200]. Galactosemia II is an autosomal recessive deficiency characterized by congenital cataracts during infancy and presenile cataracts in the adult population. The cataracts are secondary to accumulation of galactitol in the lenses.<ref>PMID:10521295</ref> <ref>PMID:10790206</ref> <ref>PMID:11231902</ref> <ref>PMID:11139256</ref> <ref>PMID:12694189</ref> <ref>PMID:15024738</ref>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GALK1_HUMAN GALK1_HUMAN]] Major enzyme for galactose metabolism.
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[https://www.uniprot.org/uniprot/GALK1_HUMAN GALK1_HUMAN] Major enzyme for galactose metabolism.
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==See Also==
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*[[Galactokinase|Galactokinase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Galactokinase]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arrowsmith, C]]
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[[Category: Arrowsmith C]]
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[[Category: Bezerra, G A]]
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[[Category: Bezerra GA]]
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[[Category: Bountra, C]]
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[[Category: Bountra C]]
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[[Category: Edwards, A]]
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[[Category: Edwards A]]
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[[Category: Lai, K]]
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[[Category: Lai K]]
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[[Category: Mackinnon, S]]
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[[Category: Mackinnon S]]
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[[Category: Structural genomic]]
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[[Category: Williams E]]
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[[Category: Williams, E]]
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[[Category: Yue WW]]
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[[Category: Yue, W W]]
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[[Category: Zhang M]]
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[[Category: Zhang, M]]
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[[Category: Adp]]
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[[Category: Galactose]]
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[[Category: Ghmp kinase]]
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[[Category: Leloir pathway]]
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[[Category: Sgc]]
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[[Category: Transferase]]
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Current revision

Structure of human galactokinase in complex with galactose and ADP

PDB ID 6gr2

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

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