1fu3

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<StructureSection load='1fu3' size='340' side='right'caption='[[1fu3]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='1fu3' size='340' side='right'caption='[[1fu3]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1fu3]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FU3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FU3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1fu3]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FU3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FU3 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fu3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fu3 OCA], [http://pdbe.org/1fu3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1fu3 RCSB], [http://www.ebi.ac.uk/pdbsum/1fu3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1fu3 ProSAT]</span></td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fu3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fu3 OCA], [https://pdbe.org/1fu3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fu3 RCSB], [https://www.ebi.ac.uk/pdbsum/1fu3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fu3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CO16A_CONTE CO16A_CONTE]] Delta-conotoxins bind to site 6 of voltage-gated sodium channels (Nav) and inhibit the inactivation process. Binding of this toxin is strongly calcium-dependent but not voltage-dependent. The binding site is most likely on the extracellular side of the sodium channel. Binds receptor sites on both mollusk and rat central nervous system, but despite its high affinity binding to rat sodium channel, it has no functional effect in vivo and in vitro on it. Has also no effect on Gambusia fish. Is important in mollusk for the paralysis of the prey. Upon injection of the peptide, a subordinate lobster assumes an exaggerated dominant posture (of a 'King-Kong' lobster!).
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[[https://www.uniprot.org/uniprot/CO16A_CONTE CO16A_CONTE]] Delta-conotoxins bind to site 6 of voltage-gated sodium channels (Nav) and inhibit the inactivation process. Binding of this toxin is strongly calcium-dependent but not voltage-dependent. The binding site is most likely on the extracellular side of the sodium channel. Binds receptor sites on both mollusk and rat central nervous system, but despite its high affinity binding to rat sodium channel, it has no functional effect in vivo and in vitro on it. Has also no effect on Gambusia fish. Is important in mollusk for the paralysis of the prey. Upon injection of the peptide, a subordinate lobster assumes an exaggerated dominant posture (of a 'King-Kong' lobster!).
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==

Revision as of 07:08, 24 March 2021

THREE-DIMENSIONAL STRUCTURE IN SOLUTION OF THE SODIUM CHANNEL AGONIST/ANTAGONIST DELTA-CONOTOXIN TXVIA

PDB ID 1fu3

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