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4zbb

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Revision as of 07:47, 10 May 2023

Crystal structure of the glutathione transferase URE2P8 from Phanerochaete chrysosporium complexed with glutathionyl-S-dinitrobenzene.

Structural highlights

4zbb is a 4 chain structure with sequence from Phanerodontia chrysosporium. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	, , ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

A0A0R4I985_PHACH

Publication Abstract from PubMed

The intracellular systems of detoxification are crucial for the survival of wood degrading fungi. Within these systems, glutathione transferases could play a major role since this family of enzymes is specifically extended in lignolytic fungi. In particular the Ure2p class represents one third of the total GST number in Phanerochaete chrysosporium. These proteins have been phylogenetically split into two subclasses called Ure2pA and Ure2pB. Ure2pB can be classified as Nu GSTs because of shared structural and functional features with previously characterized bacterial isoforms. Ure2pA can rather be qualified as Nu-like GSTs since they exhibit a number of differences. Ure2pA possess a classical transferase activity, a more divergent catalytic site and a higher structural flexibility for some of them, compared to Nu GSTs. The characterization of four members of this Ure2pA subclass (PcUre2pA4, PcUre2pA5, PcUre2pA6 and PcUre2pA8) revealed specific functional and structural features, suggesting that these enzymes have rapidly evolved and differentiated, probably to adapt to the complex chemical environment associated with wood decomposition.

Evolutionary divergence of Ure2pA glutathione transferases in wood degrading fungi.,Roret T, Thuillier A, Favier F, Gelhaye E, Didierjean C, Morel-Rouhier M Fungal Genet Biol. 2015 Oct;83:103-12. doi: 10.1016/j.fgb.2015.09.002. Epub 2015 , Sep 5. PMID:26348000^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Roret T, Thuillier A, Favier F, Gelhaye E, Didierjean C, Morel-Rouhier M. Evolutionary divergence of Ure2pA glutathione transferases in wood degrading fungi. Fungal Genet Biol. 2015 Oct;83:103-12. doi: 10.1016/j.fgb.2015.09.002. Epub 2015 , Sep 5. PMID:26348000 doi:http://dx.doi.org/10.1016/j.fgb.2015.09.002

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4zbb"

Categories: Large Structures | Phanerodontia chrysosporium | Didierjean C | Roret T

@@ Line 3: / Line 3: @@
 <StructureSection load='4zbb' size='340' side='right'caption='[[4zbb]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4zbb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Chrysosporium_pruinosum_(gilman_&_abbott)_carmich. Chrysosporium pruinosum (gilman & abbott) carmich.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZBB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZBB FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4zbb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Phanerodontia_chrysosporium Phanerodontia chrysosporium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZBB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZBB FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GDN:GLUTATHIONE+S-(2,4+DINITROBENZENE)'>GDN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GDN:GLUTATHIONE+S-(2,4+DINITROBENZENE)'>GDN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zbb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zbb OCA], [http://pdbe.org/4zbb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zbb RCSB], [http://www.ebi.ac.uk/pdbsum/4zbb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zbb ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zbb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zbb OCA], [https://pdbe.org/4zbb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zbb RCSB], [https://www.ebi.ac.uk/pdbsum/4zbb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zbb ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/A0A0R4I985_PHACH A0A0R4I985_PHACH]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 21: / Line 23: @@
 </StructureSection>
 [[Category: Large Structures]]
-[[Category: Didierjean, C]]
+[[Category: Phanerodontia chrysosporium]]
-[[Category: Roret, T]]
+[[Category: Didierjean C]]
-[[Category: Glutathione transferase]]
+[[Category: Roret T]]
-[[Category: Gst fold]]
-[[Category: Transferase]]

4zbb

From Proteopedia

Revision as of 07:47, 10 May 2023

Crystal structure of the glutathione transferase URE2P8 from Phanerochaete chrysosporium complexed with glutathionyl-S-dinitrobenzene.

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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