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Exonuclease

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Current revision (07:56, 25 June 2019) (edit) (undo)
 
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== 3D Structures of exonuclease ==
 
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
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{{#tree:id=OrganizedByTopic|openlevels=0|
 
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*ExN-I
 
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**[[3qea]], [[3qeb]], [[5v04]], [[5v05]], [[5v06]], [[5v0b]], [[5v0c]], [[5v0d]], [[5v0e]], [[5uzv]] - hExN-I + DNA - human<br />
 
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**[[3qe9]], [[5v07]], [[5v08]], [[5v09]], [[5v0a]] – hExN-I (mutant) + DNA – human<br />
 
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**[[1fxx]], [[3c95]] – EcExN-I – ''Escherichia coli''<br />
 
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**[[2qxf]] - EcExN-I + TMP<br />
 
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**[[3hl8]], [[3hp9]] - EcExN-I + inhibitor<br />
 
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**[[3c94]] - EcExN-I + DNA-binding C terminal peptide<br />
 
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**[[4jrp]], [[4jrq]], [[4js5]], [[4js4]], [[4hcc]], [[4hcb]] – EcExN-I + DNA<br />
 
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**[[4rg8]] – ExN-I (mutant) – ''Methylocaldum szegedienes''<br />
 
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**[[5fiq]], [[5fis]] – ExN-I ExN domain – silkworm<br />
 
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*ExN-III
 
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**[[2voa]] – AfExN-III (mutant) + DNA – ''Archaeoglobus fulgidus''<br />
 
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**[[3g1k]] - MtExN-III – ''Methanothermobacter thermaautotrophicus''<br />
 
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**[[3g3c]], [[3g4t]] - MtExN-III + DNA<br />
 
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**[[3fzi]], [[3g8v]], [[3g91]] - MtExN-III (mutant) <br />
 
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**[[3g00]], [[3g0r]], [[3g2c]], [[3g2d]], [[3g38]], [[3g3y]], [[3ga6]] - MtExN-III (mutant) + DNA<br />
 
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**[[3g0a]] - MtExN-III (mutant) + Mn<br />
 
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**[[1ako]] – EcExN-III
 
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*ExN-IV
 
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**[[2jc4]] – ExN-IV – ''Nisseria meningitides''
 
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*ExN-V
 
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**[[1w36]], [[3k70]] – EcExN-V α+β+γ + DNA hairpin<br />
 
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**[[3e1s]] - EcExN-V RECD subunit<br />
 
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**[[3gp8]] - DrExN-V RECD subunit + DNA – ''Deinococcus radiodurans''<br />
 
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**[[3gpl]] - DrExN-V RECD subunit + DNA + ADPNP
 
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*ExN-VII
 
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**[[1vp7]] – ExN-VII small subunit – ''Bordetella pertussis''
 
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*ExN-VIII
 
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**[[3h4r]] - EcExN-VIII C terminal (mutant)
 
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*ExN-X
 
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**[[4fzz]], [[4fzy]], [[4fzx]] - EcExN-X + DNA<br />
 
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*5’ ExN or exodeoxyribonuclease
 
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**[[1ut5]], [[1ut8]] – T5-5’-ExN + metal – Bacteriophage T5<br />
 
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**[[1exn]], [[1xo1]] - T5-5’-ExN (mutant)<br />
 
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**[[5hmm]] - EpT5-5’-ExN + metal – Escherichia phage T5<br />
 
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**[[5hml]] - EpT5-5’-ExN (mutant) + metal <br />
 
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**[[5hnk]], [[5hp4]] - EpT5-5’-ExN (mutant) + metal + DNA<br />
 
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**[[1avq]] – BlExN λ (mutant) – Bacteriophage λ<br />
 
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**[[3slp]], [[4wuz]] - BlExN λ + DNA<br />
 
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**[[3sm4]] - BlExN λ (mutant) + DNA<br />
 
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**[[3k93]] – ExN – Haemophilus somnus
 
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*Exosome complex ExN see [[Exosome]]
 
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*ssDNA-specific ExN
 
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**[[5ght]] – TkExN – ''Thermococcus kodakarensis''<br />
 
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**[[5ghs]], [[5ghr]] – TkExN + polypeptide<br />
 
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**[[5f54]] – DrExN + dTMP<br />
 
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**[[5f55]] – DrExN + DNA<br />
 
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**[[5f56]] – DrExN + DNA + polypeptide<br />
 
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*3'-5' ExN
 
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**[[4qoz]], [[4l8r]] – hExN + histone RNA hairpin-binding protein + RNA<br />
 
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**[[4yor]], [[4yot]], [[4you]] – PhExN phoexo I – ''Pyrococcus horikoshii''<br />
 
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**[[4yov]], [[4yow]], [[4yox]], [[4yoy]] – PhExN phoexo I (mutant) + DNA<br />
 
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*5’-3’ ExN
 
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**[[6c33]] – MsExN – ''Mycobacterium smegmatis''<br />
 
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**[[6c34]], [[6c35]], [[6c36]] – MsExN (mutant)<br />
 
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*ExN Trex
 
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**[[1y97]] – hExN Trex2<br />
 
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**[[2o4g]] - mExN Trex1 + nucleotide – mouse<br />
 
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**[[3mxj]] - mExN Trex1<br />
 
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**[[2o4i]], [[3mxi]], [[3mxm]], [[3u3y]], [[3u6f]] - mExN Trex1 (mutant) + polynucleotide<br />
 
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**[[2oa8]], [[5ywv]], [[5ywu]], [[5ywt]], [[5yws]] - mExN Trex1 + DNA<br />
 
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**[[4ynq]] - mExN Trex1 (mutant) + DNA<br />
 
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**[[3b6o]], [[3b6p]] - mExN Trex1 + ion inhibitor<br />
 
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**[[6a45]] - mExN Trex2<br />
 
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**[[6a4b]], [[6a47]] - mExN Trex2 + DNA<br />
 
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**[[6a46]] - mExN Trex2 + nucleotide<br />
 
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*Other ExN
 
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**[[1w0h]] – hExn Eri1 nuclease domain <br />
 
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**[[1zbu]] - hExn Eri1<br />
 
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**[[1zbh]] - hExn Eri1 (mutant) + DNA<br />
 
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**[[5aho]] – hExN Apollo<br />
 
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**[[5zyw]] – hExN mitochondrial genome repair 1<br />
 
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**[[5zyv]], [[5zyu]], [[5zyt]] – hExN mitochondrial genome repair 1 + DNA<br />
 
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**[[3e2v]] – yExN <br />
 
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**[[2w45]] – H4ExN alkaline - Herpesvirus 4<br />
 
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**[[2w4b]] - H4ExN alkaline (mutant)<br />
 
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**[[3syy]] - LhExN alkaline – ''Laribacter hongkongensis''<br />
 
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**[[3sz4]] - LhExN alkaline + AMP<br />
 
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**[[3sz5]] - LhExN alkaline + polynucleotide<br />
 
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**[[4lty]], [[4lu9]], [[4m0v]] – EcExN sbcD<br />
 
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**[[6m9k]] - ExN + recombination protein BET – Escherichia phage λ<br />
 
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**[[1ir6]], [[2zxo]], [[2zxp]], [[2zxr]] – ExN Recj – ''Thermus thermophiles''<br />
 
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}}
 
== References ==
== References ==

Current revision

E. coli exonuclease I complex with phosphate, glycerol and Mg+2 ion (PDB code 1fxx)

Drag the structure with the mouse to rotate

References

  1. ↑ Mukherjee D, Fritz DT, Kilpatrick WJ, Gao M, Wilusz J. Analysis of RNA exonucleolytic activities in cellular extracts. Methods Mol Biol. 2004;257:193-212. PMID:14770007 doi:http://dx.doi.org/10.1385/1-59259-750-5:193
  2. ↑ Breyer WA, Matthews BW. Structure of Escherichia coli exonuclease I suggests how processivity is achieved. Nat Struct Biol. 2000 Dec;7(12):1125-8. PMID:11101894 doi:10.1038/81978

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