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Exportin

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</StructureSection>
</StructureSection>
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==3D structures of exportin==
 
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
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{{#tree:id=OrganizedByTopic|openlevels=0|
 
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*XPO-1
 
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**[[4bsm]], [[4bsn]] – hXPO – human<br />
 
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**[[1w9c]] – hXPO C terminal 6 heat repeats <br />
 
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**[[3vyc]] – yXPO (mutant) - yeast<br />
 
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**[[4fgv]] – XPO – ''Chaetomium thermophilum''<br />
 
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*XPO-1 complexes
 
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**[[3gb8]] – hXPO + RNA U transporter 1 <br />
 
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**[[3gjx]] – hXPO + RNA U transporter 1 + RAN<br />
 
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**[[5dis]] – hXPO + RAN + RNA U transporter 1 + MBP<br />
 
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**[[3m1i]], [[4gpt]], [[4gmx]], [[4hat]], [[4hb2]], [[5jlj]] – yXPO (mutant) + RAN + RANBP1 <br />
 
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**[[3wyf]] – yXPO + RAN + RANBP1 <br />
 
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**[[3wyg]] – yXPO + RAN + PKI-α<br />
 
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**[[5zpu]], [[5ytb]], [[5yst]], [[5uro]] - yXPO (mutant) + RAN + RANBP1 + GTP<br />
 
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**[[5ysu]] - yXPO (mutant) + RAN + RANBP1 + GTP + plumbagin<br />
 
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**[[4hau]], [[4hav]], [[4haw]], [[4hax]], [[4hay]], [[4haz]], [[4hb0]], [[4hb3]], [[4hb4]] – yXPO (mutant) + RAN + RANBP1 + antibiotic<br />
 
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**[[5dh9]], [[5dha]], [[5dhf]], [[5di9]], [[5uwj]], [[5dif]] - yXPO (mutant) + RAN + RANBP1 + signal peptide<br />
 
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**[[5uwo]], [[5uwp]], [[5uwq]], [[5uwr]], [[5uws]], [[5uwt]], [[5uwu]], [[5uww]], [[5uwi]], [[5uwh]] - yXPO + RAN + RANBP1 + signal peptide<br />
 
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**[[6cit]], [[6a38]] - yXPO + RAN + RANBP1 + NS2 peptide<br />
 
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**[[6a3a]], [[6a3b]], [[6a3c]], [[6a3e]] - yXPO (mutant) + RAN + RANBP1 + NS2 peptide<br />
 
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**[[5xoj]] - yXPO (mutant) + GSP1P + PKI-a + NUP42 peptide + GTP<br />
 
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**[[3nby]], [[3nbz]], [[3nc0]] – mXPO + RNA U transporter 1 + RANBP1 - mouse<br />
 
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**[[3nc1]] – mXPO + RANBP1<br />
 
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**[[2l1l]] – hXPO residues 504-630 + PKI-α - NMR<br />
 
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*XPO-t
 
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**[[3ibv]] – fyXPO – fission yeast<br />
 
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**[[3icq]] – fyXPO + RAN homolog + RNA <br />
 
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*XPO-4
 
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**[[5dlq]] – mXPO (mutant) + RAN + EIF5A1<br />
 
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*XPO-5
 
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**[[5yu7]] – hXPO <br />
 
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**[[5yu6]] – hXPO + peptide + RAN <br />
 
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**[[3a6p]] – hXPO + peptide + pre-microRNA <br />
 
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}}
 
== References ==
== References ==

Revision as of 09:39, 25 June 2019

Structure of yeast exportin-5 (magenta) complex with GTPaseRan (cyan), Mg+2 (green) and RNA (PDB code 3icq).

Drag the structure with the mouse to rotate

References

  1. Kohler A, Hurt E. Exporting RNA from the nucleus to the cytoplasm. Nat Rev Mol Cell Biol. 2007 Oct;8(10):761-73. PMID:17786152 doi:http://dx.doi.org/10.1038/nrm2255
  2. Cook AG, Fukuhara N, Jinek M, Conti E. Structures of the tRNA export factor in the nuclear and cytosolic states. Nature. 2009 Sep 3;461(7260):60-5. PMID:19680239 doi:10.1038/nature08394

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Michal Harel, Alexander Berchansky

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