6r7l
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Ribosome-bound SecYEG translocon in a nanodisc== | |
| - | + | <StructureSection load='6r7l' size='340' side='right'caption='[[6r7l]], [[Resolution|resolution]] 6.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6r7l]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R7L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6R7L FirstGlance]. <br> | |
| - | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6r7l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r7l OCA], [http://pdbe.org/6r7l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r7l RCSB], [http://www.ebi.ac.uk/pdbsum/6r7l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r7l ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SECY_ECOLI SECY_ECOLI]] The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. SecY is required to insert newly synthesized SecY into the inner membrane. Overexpression of some hybrid proteins has been thought to jam the protein secretion apparatus resulting in cell death; while this may be true, overexpression also results in FtsH-mediated degradation of SecY.[HAMAP-Rule:MF_01465] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Escherichia coli]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Beckmann, R]] | [[Category: Beckmann, R]] | ||
| + | [[Category: Kater, L]] | ||
[[Category: Kedrov, A]] | [[Category: Kedrov, A]] | ||
| - | [[Category: | + | [[Category: Insertion intermediate]] |
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Monomeric translocon]] | ||
| + | [[Category: Nanodisc]] | ||
Revision as of 06:05, 7 August 2019
Ribosome-bound SecYEG translocon in a nanodisc
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