6s1f

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m (Protected "6s1f" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6s1f is ON HOLD
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==Structure of the kinase domain of human RIPK2 in complex with the inhibitor CSLP3==
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<StructureSection load='6s1f' size='340' side='right'caption='[[6s1f]], [[Resolution|resolution]] 3.11&Aring;' scene=''>
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Authors: Pinkas, D.M., Bufton, J.C., Kupinska, K., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.N.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6s1f]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S1F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6S1F FirstGlance]. <br>
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Description: Structure of the kinase domain of human RIPK2 in complex with the inhibitor CSLP3
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KRE:~{N}-[3-[2-azanyl-5-(4-piperazin-1-ylphenyl)pyridin-3-yl]-5-methoxy-phenyl]methanesulfonamide'>KRE</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6s1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s1f OCA], [http://pdbe.org/6s1f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6s1f RCSB], [http://www.ebi.ac.uk/pdbsum/6s1f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6s1f ProSAT]</span></td></tr>
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[[Category: Burgess-Brown, N.A]]
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</table>
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[[Category: Pinkas, D.M]]
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== Function ==
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[[http://www.uniprot.org/uniprot/RIPK2_HUMAN RIPK2_HUMAN]] Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation.<ref>PMID:14638696</ref> <ref>PMID:17054981</ref> <ref>PMID:18079694</ref> <ref>PMID:21123652</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
[[Category: Bountra, C]]
[[Category: Bountra, C]]
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[[Category: Bufton, J C]]
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[[Category: Bullock, A N]]
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[[Category: Burgess-Brown, N A]]
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[[Category: Delft, F von]]
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[[Category: Edwards, A M]]
[[Category: Kupinska, K]]
[[Category: Kupinska, K]]
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[[Category: Arrowsmith, C.H]]
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[[Category: Pinkas, D M]]
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[[Category: Von Delft, F]]
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[[Category: Ripk2 cslp3]]
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[[Category: Bullock, A.N]]
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[[Category: Signaling protein]]
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[[Category: Bufton, J.C]]
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[[Category: Edwards, A.M]]
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Revision as of 06:00, 16 October 2019

Structure of the kinase domain of human RIPK2 in complex with the inhibitor CSLP3

PDB ID 6s1f

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