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5a35

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Revision as of 04:36, 25 May 2023

Crystal structure of Glycine Cleavage Protein H-Like (GcvH-L) from Streptococcus pyogenes

Structural highlights

5a35 is a 1 chain structure with sequence from Streptococcus pyogenes str. Manfredo. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q1JGN4_STRPD

Publication Abstract from PubMed

Sirtuins are an ancient family of NAD(+)-dependent deacylases connected with the regulation of fundamental cellular processes including metabolic homeostasis and genome integrity. We show the existence of a hitherto unrecognized class of sirtuins, found predominantly in microbial pathogens. In contrast to earlier described classes, these sirtuins exhibit robust protein ADP-ribosylation activity. In our model organisms, Staphylococcus aureus and Streptococcus pyogenes, the activity is dependent on prior lipoylation of the target protein and can be reversed by a sirtuin-associated macrodomain protein. Together, our data describe a sirtuin-dependent reversible protein ADP-ribosylation system and establish a crosstalk between lipoylation and mono-ADP-ribosylation. We propose that these posttranslational modifications modulate microbial virulence by regulating the response to host-derived reactive oxygen species.

Identification of a Class of Protein ADP-Ribosylating Sirtuins in Microbial Pathogens.,Rack JG, Morra R, Barkauskaite E, Kraehenbuehl R, Ariza A, Qu Y, Ortmayer M, Leidecker O, Cameron DR, Matic I, Peleg AY, Leys D, Traven A, Ahel I Mol Cell. 2015 Jul 16;59(2):309-20. doi: 10.1016/j.molcel.2015.06.013. Epub 2015 , Jul 9. PMID:26166706^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Rack JG, Morra R, Barkauskaite E, Kraehenbuehl R, Ariza A, Qu Y, Ortmayer M, Leidecker O, Cameron DR, Matic I, Peleg AY, Leys D, Traven A, Ahel I. Identification of a Class of Protein ADP-Ribosylating Sirtuins in Microbial Pathogens. Mol Cell. 2015 Jul 16;59(2):309-20. doi: 10.1016/j.molcel.2015.06.013. Epub 2015 , Jul 9. PMID:26166706 doi:http://dx.doi.org/10.1016/j.molcel.2015.06.013

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5a35"

@@ Line 3: / Line 3: @@
 <StructureSection load='5a35' size='340' side='right'caption='[[5a35]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5a35]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Strpg Strpg]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A35 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A35 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5a35]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes_str._Manfredo Streptococcus pyogenes str. Manfredo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A35 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A35 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene></td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5a3a|5a3a]], [[5a3b|5a3b]], [[5a3c|5a3c]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a35 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a35 OCA], [https://pdbe.org/5a35 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a35 RCSB], [https://www.ebi.ac.uk/pdbsum/5a35 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a35 ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a35 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a35 OCA], [http://pdbe.org/5a35 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a35 RCSB], [http://www.ebi.ac.uk/pdbsum/5a35 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5a35 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q1JGN4_STRPD Q1JGN4_STRPD]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 22: / Line 23: @@
 </StructureSection>
 [[Category: Large Structures]]
-[[Category: Strpg]]
+[[Category: Streptococcus pyogenes str. Manfredo]]
-[[Category: Ahel, I]]
+[[Category: Ahel I]]
-[[Category: Ariza, A]]
+[[Category: Ariza A]]
-[[Category: Barkauskaite, E]]
+[[Category: Barkauskaite E]]
-[[Category: Cameron, D R]]
+[[Category: Cameron DR]]
-[[Category: Kraehenbuehl, R]]
+[[Category: Kraehenbuehl R]]
-[[Category: Leidecker, O]]
+[[Category: Leidecker O]]
-[[Category: Leys, D]]
+[[Category: Leys D]]
-[[Category: Matic, I]]
+[[Category: Matic I]]
-[[Category: Morra, R]]
+[[Category: Morra R]]
-[[Category: Ortmayer, M]]
+[[Category: Ortmayer M]]
-[[Category: Peleg, A Y]]
+[[Category: Peleg AY]]
-[[Category: Qu, Y]]
+[[Category: Qu Y]]
-[[Category: Rack, J G.M]]
+[[Category: Rack JGM]]
-[[Category: Traven, A]]
+[[Category: Traven A]]
-[[Category: Adp-ribosylation]]
-[[Category: Lipoylation]]
-[[Category: Transport protein]]

5a35

From Proteopedia

Revision as of 04:36, 25 May 2023

Crystal structure of Glycine Cleavage Protein H-Like (GcvH-L) from Streptococcus pyogenes

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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