|
|
| Line 3: |
Line 3: |
| | <StructureSection load='5a9b' size='340' side='right'caption='[[5a9b]], [[Resolution|resolution]] 1.88Å' scene=''> | | <StructureSection load='5a9b' size='340' side='right'caption='[[5a9b]], [[Resolution|resolution]] 1.88Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[5a9b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bmcpv Bmcpv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A9B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A9B FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5a9b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bombyx_mori_cypovirus_1 Bombyx mori cypovirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A9B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A9B FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5a8s|5a8s]], [[5a8t|5a8t]], [[5a8u|5a8u]], [[5a8v|5a8v]], [[5a96|5a96]], [[5a98|5a98]], [[5a99|5a99]], [[5a9a|5a9a]], [[5a9c|5a9c]], [[5a9p|5a9p]]</td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a9b OCA], [https://pdbe.org/5a9b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a9b RCSB], [https://www.ebi.ac.uk/pdbsum/5a9b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a9b ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a9b OCA], [http://pdbe.org/5a9b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a9b RCSB], [http://www.ebi.ac.uk/pdbsum/5a9b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5a9b ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/PYHD_CPVBM PYHD_CPVBM]] Major component of the virus occlusion bodies, which are large proteinaceous structures (polyhedra), that protect the virus from the outside environment for extended periods until they are ingested by insect larvae. | + | [https://www.uniprot.org/uniprot/PYHD_CPVBM PYHD_CPVBM] Major component of the virus occlusion bodies, which are large proteinaceous structures (polyhedra), that protect the virus from the outside environment for extended periods until they are ingested by insect larvae. |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
| Line 18: |
Line 17: |
| | </div> | | </div> |
| | <div class="pdbe-citations 5a9b" style="background-color:#fffaf0;"></div> | | <div class="pdbe-citations 5a9b" style="background-color:#fffaf0;"></div> |
| | + | |
| | + | ==See Also== |
| | + | *[[Polyhedrin|Polyhedrin]] |
| | == References == | | == References == |
| | <references/> | | <references/> |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Bmcpv]] | + | [[Category: Bombyx mori cypovirus 1]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Axford, D]] | + | [[Category: Axford D]] |
| - | [[Category: Evans, G]] | + | [[Category: Evans G]] |
| - | [[Category: Ginn, H M]] | + | [[Category: Ginn HM]] |
| - | [[Category: Ji, X]] | + | [[Category: Ji X]] |
| - | [[Category: Owen, R]] | + | [[Category: Owen R]] |
| - | [[Category: Stuart, D I]] | + | [[Category: Stuart DI]] |
| - | [[Category: Sutton, G]] | + | [[Category: Sutton G]] |
| - | [[Category: Insect virus occlusion body]]
| + | |
| - | [[Category: Microcrystal]]
| + | |
| - | [[Category: Viral protein]]
| + | |
| Structural highlights
Function
PYHD_CPVBM Major component of the virus occlusion bodies, which are large proteinaceous structures (polyhedra), that protect the virus from the outside environment for extended periods until they are ingested by insect larvae.
Publication Abstract from PubMed
Polyhedra represent an ancient system used by a number of insect viruses to protect virions during long periods of environmental exposure. We present high resolution crystal structures of polyhedra for seven previously uncharacterised types of cypoviruses, four using ab initio selenomethionine phasing (two of these required over 100 selenomethionine crystals each). Approximately 80% of residues are structurally equivalent between all polyhedrins (pairwise rmsd 1.5A), whilst pairwise sequence identities, based on structural alignment, are as little as 12%. These structures illustrate the effect of 400million years of evolution on a system where the crystal lattice is the functionally conserved feature in the face of massive sequence variability. The conservation of crystal contacts is maintained across most of the molecular surface, except for a dispensable virus recognition domain. By spreading the contacts over so much of the protein surface the lattice remains robust in the face of many individual changes. Overall these unusual structural constraints seem to have skewed the molecule's evolution so that surface residues are almost as conserved as the internal residues.
Polyhedra structures and the evolution of the insect viruses.,Ji X, Axford D, Owen R, Evans G, Ginn HM, Sutton G, Stuart DI J Struct Biol. 2015 Aug 18. pii: S1047-8477(15)30047-2. doi:, 10.1016/j.jsb.2015.08.009. PMID:26291392[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Ji X, Axford D, Owen R, Evans G, Ginn HM, Sutton G, Stuart DI. Polyhedra structures and the evolution of the insect viruses. J Struct Biol. 2015 Aug 18. pii: S1047-8477(15)30047-2. doi:, 10.1016/j.jsb.2015.08.009. PMID:26291392 doi:http://dx.doi.org/10.1016/j.jsb.2015.08.009
|
