4zj8

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<StructureSection load='4zj8' size='340' side='right'caption='[[4zj8]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
<StructureSection load='4zj8' size='340' side='right'caption='[[4zj8]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4zj8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZJ8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZJ8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4zj8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Pyrococcus_abyssi_GE5 Pyrococcus abyssi GE5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZJ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZJ8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=SUV:[(7R)-4-(5-CHLORO-1,3-BENZOXAZOL-2-YL)-7-METHYL-1,4-DIAZEPAN-1-YL][5-METHYL-2-(2H-1,2,3-TRIAZOL-2-YL)PHENYL]METHANONE'>SUV</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=SUV:[(7R)-4-(5-CHLORO-1,3-BENZOXAZOL-2-YL)-7-METHYL-1,4-DIAZEPAN-1-YL][5-METHYL-2-(2H-1,2,3-TRIAZOL-2-YL)PHENYL]METHANONE'>SUV</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4zjc|4zjc]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zj8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zj8 OCA], [https://pdbe.org/4zj8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zj8 RCSB], [https://www.ebi.ac.uk/pdbsum/4zj8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zj8 ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HCRTR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zj8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zj8 OCA], [http://pdbe.org/4zj8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zj8 RCSB], [http://www.ebi.ac.uk/pdbsum/4zj8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zj8 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/OX1R_HUMAN OX1R_HUMAN]] Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade (By similarity).
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[https://www.uniprot.org/uniprot/OX1R_HUMAN OX1R_HUMAN] Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade (By similarity).[https://www.uniprot.org/uniprot/Q9V2J8_PYRAB Q9V2J8_PYRAB]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Brautigam, C A]]
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[[Category: Pyrococcus abyssi GE5]]
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[[Category: Clark, L]]
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[[Category: Brautigam CA]]
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[[Category: Coleman, P]]
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[[Category: Clark L]]
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[[Category: Gotter, A L]]
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[[Category: Coleman P]]
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[[Category: Harrell, C M]]
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[[Category: Gotter AL]]
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[[Category: Renger, J J]]
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[[Category: Harrell CM]]
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[[Category: Rosenbaum, D M]]
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[[Category: Renger JJ]]
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[[Category: Shao, Z]]
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[[Category: Rosenbaum DM]]
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[[Category: Yin, J]]
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[[Category: Shao Z]]
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[[Category: Orexin]]
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[[Category: Yin J]]
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[[Category: Sb674042]]
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[[Category: Signaling protein]]
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[[Category: Suvorexant]]
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Revision as of 07:30, 18 May 2023

Structures of the human OX1 orexin receptor bound to selective and dual antagonists

PDB ID 4zj8

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