Isopentenyl-diphosphate delta-isomerase

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Line 21: Line 21:
*Isopentenyl-diphosphate delta-isomerase
*Isopentenyl-diphosphate delta-isomerase
 +
**[[2icj]] – hIPPI + Mg - human<br />
 +
**[[2dho]] – hIPPI 1 (mutant) + Mn <br />
**[[1i9a]], [[2vnq]] – EcIPPI + Mn – ''Escherichia coli''<br />
**[[1i9a]], [[2vnq]] – EcIPPI + Mn – ''Escherichia coli''<br />
**[[1hx3]] – EcIPPI (mutant) + Mn<br />
**[[1hx3]] – EcIPPI (mutant) + Mn<br />
Line 26: Line 28:
**[[2g74]] – EcIPPI (mutant) + Mg + Mn<br />
**[[2g74]] – EcIPPI (mutant) + Mg + Mn<br />
**[[1hzt]] – EcIPPI <br />
**[[1hzt]] – EcIPPI <br />
-
**[[2icj]] – hIPPI + Mg - human<br />
 
-
**[[2dho]] – hIPPI 1 (mutant) + Mn <br />
 
**[[1p0k]] – BsIPPI – ''Bacillus subtilis''<br />
**[[1p0k]] – BsIPPI – ''Bacillus subtilis''<br />
**[[1p0n]] – BsIPPI + FMN<br />
**[[1p0n]] – BsIPPI + FMN<br />
Line 39: Line 39:
*Isopentenyl-diphosphate delta-isomerase complex
*Isopentenyl-diphosphate delta-isomerase complex
 +
**[[2i6k]] – hIPPI (mutant) + Mn + Mg + aminoethanol-PP<br />
 +
**[[2ick]] – hIPPI + Mn + dimethylallyl-PP<br />
 +
**[[2pny]] – hIPPI 2 + Mn + PP<br />
**[[1nfs]], [[2vnp]] – EcIPPI + Mn + Mg + dimethylamino-ethyl-PP<br />
**[[1nfs]], [[2vnp]] – EcIPPI + Mn + Mg + dimethylamino-ethyl-PP<br />
**[[1pvf]] – EcIPPI + Mn + Mg + PP<br />
**[[1pvf]] – EcIPPI + Mn + Mg + PP<br />
Line 49: Line 52:
**[[3b06]], [[2zrx]], [[2zrz]] – SsIPPI + FMN + Mg + DMAPP<br />
**[[3b06]], [[2zrx]], [[2zrz]] – SsIPPI + FMN + Mg + DMAPP<br />
**[[3b03]], [[3b04]] – SsIPPI + Mg + inhibitor<br />
**[[3b03]], [[3b04]] – SsIPPI + Mg + inhibitor<br />
-
**[[2i6k]] – hIPPI (mutant) + Mn + Mg + aminoethanol-PP<br />
 
-
**[[2ick]] – hIPPI + Mn + dimethylallyl-PP<br />
 
-
**[[2pny]] – hIPPI 2 + Mn + PP<br />
 
}}
}}

Revision as of 10:17, 5 September 2019

Structure of E. coli isopentenyl-diphosphate delta-isomerase complex with EIPP, Mg+2 (green) and Mn+2 (purple) ions and EIPP (PDB code 1nfz).

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3D structures of isopentenyl-diphosphate delta-isomerase

Updated on 05-September-2019

References

  1. Reardon JE, Abeles RH. Mechanism of action of isopentenyl pyrophosphate isomerase: evidence for a carbonium ion intermediate. Biochemistry. 1986 Sep 23;25(19):5609-16. PMID:3022798
  2. Wouters J, Oudjama Y, Barkley SJ, Tricot C, Stalon V, Droogmans L, Poulter CD. Catalytic mechanism of Escherichia coli isopentenyl diphosphate isomerase involves Cys-67, Glu-116, and Tyr-104 as suggested by crystal structures of complexes with transition state analogues and irreversible inhibitors. J Biol Chem. 2003 Apr 4;278(14):11903-8. Epub 2003 Jan 22. PMID:12540835 doi:http://dx.doi.org/10.1074/jbc.M212823200

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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