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6o2x

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Current revision (07:03, 11 October 2023) (edit) (undo)
 
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<StructureSection load='6o2x' size='340' side='right'caption='[[6o2x]], [[Resolution|resolution]] 1.19&Aring;' scene=''>
<StructureSection load='6o2x' size='340' side='right'caption='[[6o2x]], [[Resolution|resolution]] 1.19&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6o2x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O2X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6O2X FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6o2x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O2X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6O2X FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.193&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SCH:S-METHYL-THIO-CYSTEINE'>SCH</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SCH:S-METHYL-THIO-CYSTEINE'>SCH</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cruzipain Cruzipain], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.51 3.4.22.51] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6o2x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o2x OCA], [https://pdbe.org/6o2x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6o2x RCSB], [https://www.ebi.ac.uk/pdbsum/6o2x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6o2x ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6o2x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o2x OCA], [http://pdbe.org/6o2x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o2x RCSB], [http://www.ebi.ac.uk/pdbsum/6o2x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o2x ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CYSP_TRYCR CYSP_TRYCR]] Hydrolyzes chromogenic peptides at the carboxyl Arg or Lys; requires at least one more amino acid, preferably Arg, Phe, Val or Leu, between the terminal Arg or Lys and the amino-blocking group. The cysteine protease may play an important role in the development and differentiation of the parasites at several stages of their life cycle.
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[https://www.uniprot.org/uniprot/CYSP_TRYCR CYSP_TRYCR] Hydrolyzes chromogenic peptides at the carboxyl Arg or Lys; requires at least one more amino acid, preferably Arg, Phe, Val or Leu, between the terminal Arg or Lys and the amino-blocking group. The cysteine protease may play an important role in the development and differentiation of the parasites at several stages of their life cycle.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6o2x" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6o2x" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Cruzain|Cruzain]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cruzipain]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Trycr]]
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[[Category: Trypanosoma cruzi]]
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[[Category: Brandstetter, H]]
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[[Category: Brandstetter H]]
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[[Category: Dall, E]]
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[[Category: Dall E]]
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[[Category: Ferreira, R S]]
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[[Category: Ferreira RS]]
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[[Category: Silva, E B]]
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[[Category: Silva EB]]
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[[Category: Autocatalytic cleavage]]
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[[Category: Cysteine protease]]
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[[Category: Hydrolase]]
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[[Category: Protease]]
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Current revision

Structure of cruzain bound to MMTS inhibitor

PDB ID 6o2x

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