5ak0

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<StructureSection load='5ak0' size='340' side='right'caption='[[5ak0]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
<StructureSection load='5ak0' size='340' side='right'caption='[[5ak0]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ak0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AK0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AK0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ak0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AK0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AK0 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8V1:(2S)-N-[4-[1-METHYL-3-(1-METHYLPYRAZOL-4-YL)INDOL-5-YL]OXYPHENYL]PYRROLIDINE-2-CARBOXAMIDE'>8V1</scene>, <scene name='pdbligand=F6P:FRUCTOSE-6-PHOSPHATE'>F6P</scene>, <scene name='pdbligand=PHS:PHOSPHONIC+ACID'>PHS</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8V1:(2S)-N-[4-[1-METHYL-3-(1-METHYLPYRAZOL-4-YL)INDOL-5-YL]OXYPHENYL]PYRROLIDINE-2-CARBOXAMIDE'>8V1</scene>, <scene name='pdbligand=F6P:FRUCTOSE-6-PHOSPHATE'>F6P</scene>, <scene name='pdbligand=PHS:PHOSPHONIC+ACID'>PHS</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ajv|5ajv]], [[5ajw|5ajw]], [[5ajx|5ajx]], [[5ajy|5ajy]], [[5ajz|5ajz]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ak0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ak0 OCA], [https://pdbe.org/5ak0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ak0 RCSB], [https://www.ebi.ac.uk/pdbsum/5ak0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ak0 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ak0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ak0 OCA], [http://pdbe.org/5ak0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ak0 RCSB], [http://www.ebi.ac.uk/pdbsum/5ak0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ak0 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/F263_HUMAN F263_HUMAN]] Synthesis and degradation of fructose 2,6-bisphosphate.
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[https://www.uniprot.org/uniprot/F263_HUMAN F263_HUMAN] Synthesis and degradation of fructose 2,6-bisphosphate.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Boyd, S]]
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[[Category: Boyd S]]
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[[Category: Brookfield, J L]]
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[[Category: Brookfield JL]]
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[[Category: Critchlow, S E]]
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[[Category: Critchlow SE]]
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[[Category: Cumming, I A]]
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[[Category: Cumming IA]]
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[[Category: Curtis, N J]]
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[[Category: Curtis NJ]]
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[[Category: Debreczeni, J E]]
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[[Category: Debreczeni JE]]
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[[Category: Degorce, S L]]
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[[Category: Degorce SL]]
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[[Category: Donald, C]]
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[[Category: Donald C]]
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[[Category: Evans, N J]]
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[[Category: Evans NJ]]
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[[Category: Groombridge, S]]
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[[Category: Groombridge S]]
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[[Category: Hopcroft, P]]
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[[Category: Hopcroft P]]
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[[Category: Jones, N P]]
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[[Category: Jones NP]]
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[[Category: Kettle, J G]]
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[[Category: Kettle JG]]
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[[Category: Lamont, S]]
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[[Category: Lamont S]]
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[[Category: Lewis, H J]]
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[[Category: Lewis HJ]]
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[[Category: MacFaull, P]]
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[[Category: MacFaull P]]
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[[Category: McLoughlin, S B]]
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[[Category: McLoughlin SB]]
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[[Category: Rigoreau, L J.M]]
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[[Category: Rigoreau LJM]]
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[[Category: Smith, J M]]
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[[Category: Smith JM]]
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[[Category: St-Gallay, S]]
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[[Category: St-Gallay S]]
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[[Category: Stock, J K]]
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[[Category: Stock JK]]
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[[Category: Wheatley, E R]]
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[[Category: Wheatley ER]]
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[[Category: Wingfield, J]]
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[[Category: Wingfield J]]
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[[Category: Winter, J]]
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[[Category: Winter J]]
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[[Category: Transferase]]
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Revision as of 05:05, 25 May 2023

Human PFKFB3 in complex with an indole inhibitor 6

PDB ID 5ak0

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