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5agq

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Current revision (04:58, 25 May 2023) (edit) (undo)
 
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==Solution structure of the TAM domain of human TIP5 BAZ2A involved in epigenetic regulation of rRNA genes==
==Solution structure of the TAM domain of human TIP5 BAZ2A involved in epigenetic regulation of rRNA genes==
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<StructureSection load='5agq' size='340' side='right'caption='[[5agq]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='5agq' size='340' side='right'caption='[[5agq]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5agq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AGQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AGQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5agq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AGQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AGQ FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5agq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5agq OCA], [http://pdbe.org/5agq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5agq RCSB], [http://www.ebi.ac.uk/pdbsum/5agq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5agq ProSAT]</span></td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5agq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5agq OCA], [https://pdbe.org/5agq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5agq RCSB], [https://www.ebi.ac.uk/pdbsum/5agq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5agq ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BAZ2A_HUMAN BAZ2A_HUMAN]] Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity).
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[https://www.uniprot.org/uniprot/BAZ2A_HUMAN BAZ2A_HUMAN] Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Anosova, I]]
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[[Category: Anosova I]]
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[[Category: Grummt, I]]
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[[Category: Grummt I]]
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[[Category: Kateb, F]]
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[[Category: Kateb F]]
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[[Category: Melnik, S]]
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[[Category: Melnik S]]
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[[Category: Sattler, M]]
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[[Category: Sattler M]]
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[[Category: Tripsianes, K]]
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[[Category: Tripsianes K]]
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[[Category: Epigenetic]]
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[[Category: Protein rna interaction]]
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[[Category: Rrna gene silencing]]
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[[Category: Tam domain]]
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[[Category: Tip5/baz2a]]
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[[Category: Transcription]]
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Current revision

Solution structure of the TAM domain of human TIP5 BAZ2A involved in epigenetic regulation of rRNA genes

PDB ID 5agq

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