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6s4n
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==LXRbeta ligand binding domain in comlpex with small molecule inhibitors== | |
| - | + | <StructureSection load='6s4n' size='340' side='right'caption='[[6s4n]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6s4n]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S4N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6S4N FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KUW:2-[5-chloranyl-6-[4-[[1,1,3-tris(oxidanylidene)-5-phenyl-2-propan-2-yl-1,2-thiazol-4-yl]amino]piperidin-1-yl]pyridin-3-yl]ethanoic+acid'>KUW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6s4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s4n OCA], [http://pdbe.org/6s4n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6s4n RCSB], [http://www.ebi.ac.uk/pdbsum/6s4n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6s4n ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NR1H2_HUMAN NR1H2_HUMAN]] Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Jansson, A]] | [[Category: Jansson, A]] | ||
[[Category: Sandmark, J]] | [[Category: Sandmark, J]] | ||
| + | [[Category: Liver x receptor beta]] | ||
| + | [[Category: Lxr beta]] | ||
| + | [[Category: Lxrb]] | ||
| + | [[Category: Nuclear hormone receptor]] | ||
| + | [[Category: Nuclear protein]] | ||
| + | [[Category: Receptor ligand binding domain]] | ||
Revision as of 06:57, 27 November 2019
LXRbeta ligand binding domain in comlpex with small molecule inhibitors
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