6a9s

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Current revision (05:02, 21 November 2024) (edit) (undo)
 
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<StructureSection load='6a9s' size='340' side='right'caption='[[6a9s]], [[Resolution|resolution]] 1.18&Aring;' scene=''>
<StructureSection load='6a9s' size='340' side='right'caption='[[6a9s]], [[Resolution|resolution]] 1.18&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6a9s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Vaccw Vaccw]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A9S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6A9S FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6a9s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccinia_virus_WR Vaccinia virus WR]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A9S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6A9S FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.18&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VACWR149, A26L ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10254 VACCW])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6a9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a9s OCA], [https://pdbe.org/6a9s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6a9s RCSB], [https://www.ebi.ac.uk/pdbsum/6a9s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6a9s ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6a9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a9s OCA], [http://pdbe.org/6a9s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6a9s RCSB], [http://www.ebi.ac.uk/pdbsum/6a9s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6a9s ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/A26_VACCW A26_VACCW]] Plays a role in bridging the mature virion with structural protein A25. Presence of protein A26 in the virion structurally prevents direct virus-cell fusion mechanism.<ref>PMID:20538855</ref>
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[https://www.uniprot.org/uniprot/PG153_VACCW PG153_VACCW] Envelop protein that mediates acid-dependent endocytosis into host cells (PubMed:20538855). Plays an important role in endocytic entry of the virus by acting as an acid-sensitive membrane fusion suppressor (PubMed:22278246, PubMed:31220181). Low pH in host endosomes triggers conformational changes to allow de-repression of viral fusion complex activity and membrane fusion within vesicles (PubMed:31220181). Plays also a role in bridging the mature virion with structural protein OPG152.<ref>PMID:20538855</ref> <ref>PMID:22278246</ref> <ref>PMID:31220181</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Vaccw]]
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[[Category: Vaccinia virus WR]]
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[[Category: Chang, W]]
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[[Category: Chang W]]
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[[Category: Ko, T Z]]
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[[Category: Ko TZ]]
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[[Category: Liao, Y T]]
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[[Category: Liao YT]]
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[[Category: Luo, Y C]]
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[[Category: Luo YC]]
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[[Category: Wang, H C]]
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[[Category: Wang HC]]
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[[Category: Acid sensitive]]
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[[Category: Vaccinia virus]]
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[[Category: Viral protein]]
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[[Category: Virus entry]]
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Current revision

The crystal structure of vaccinia virus A26 (residues 1-397)

PDB ID 6a9s

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