6a9s
From Proteopedia
(Difference between revisions)
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<StructureSection load='6a9s' size='340' side='right'caption='[[6a9s]], [[Resolution|resolution]] 1.18Å' scene=''> | <StructureSection load='6a9s' size='340' side='right'caption='[[6a9s]], [[Resolution|resolution]] 1.18Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[6a9s]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[6a9s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccinia_virus_WR Vaccinia virus WR]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A9S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6A9S FirstGlance]. <br> |
- | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.18Å</td></tr> |
- | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
- | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6a9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a9s OCA], [https://pdbe.org/6a9s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6a9s RCSB], [https://www.ebi.ac.uk/pdbsum/6a9s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6a9s ProSAT]</span></td></tr> | |
- | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
- | [ | + | [https://www.uniprot.org/uniprot/PG153_VACCW PG153_VACCW] Envelop protein that mediates acid-dependent endocytosis into host cells (PubMed:20538855). Plays an important role in endocytic entry of the virus by acting as an acid-sensitive membrane fusion suppressor (PubMed:22278246, PubMed:31220181). Low pH in host endosomes triggers conformational changes to allow de-repression of viral fusion complex activity and membrane fusion within vesicles (PubMed:31220181). Plays also a role in bridging the mature virion with structural protein OPG152.<ref>PMID:20538855</ref> <ref>PMID:22278246</ref> <ref>PMID:31220181</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
- | [[Category: | + | [[Category: Vaccinia virus WR]] |
- | [[Category: Chang | + | [[Category: Chang W]] |
- | [[Category: Ko | + | [[Category: Ko TZ]] |
- | [[Category: Liao | + | [[Category: Liao YT]] |
- | [[Category: Luo | + | [[Category: Luo YC]] |
- | [[Category: Wang | + | [[Category: Wang HC]] |
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Current revision
The crystal structure of vaccinia virus A26 (residues 1-397)
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Categories: Large Structures | Vaccinia virus WR | Chang W | Ko TZ | Liao YT | Luo YC | Wang HC