3bfw

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{{STRUCTURE_3bfw| PDB=3bfw | SCENE= }}
{{STRUCTURE_3bfw| PDB=3bfw | SCENE= }}
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'''Crystal structure of truncated FimG (FimGt) in complex with the donor strand peptide of FimF (DSF)'''
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===Crystal structure of truncated FimG (FimGt) in complex with the donor strand peptide of FimF (DSF)===
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==Overview==
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Adhesive type 1 pili from uropathogenic Escherichia coli strains are heat and denaturant resistant, filamentous protein complexes. Individual pilus subunits associate through "donor strand complementation," whereby the incomplete immunoglobulin-like fold of each subunit is completed by the N-terminal extension of a neighboring subunit. We show that antiparallel donor strand insertion generally causes nonequilibrium behavior in protein folding and extreme activation energy barriers for dissociation of subunit-subunit complexes. We identify the most kinetically stable, noncovalent protein complex known to date. The complex between the pilus subunit FimG and the donor strand peptide of the subunit FimF shows an extrapolated dissociation half-life of 3 x 10(9) years. The 15 residue peptide forms ideal intermolecular beta sheet H-bonds with FimG over 10 residues, and its hydrophobic side chains strongly interact with the hydrophobic core of FimG. The results show that kinetic stability and nonequilibrium behavior in protein folding confers infinite stability against dissociation in extracellular protein complexes.
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(as it appears on PubMed at http://www.pubmed.gov), where 18400183 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18400183}}
==About this Structure==
==About this Structure==
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[[Category: Incomplete ig-like fold]]
[[Category: Incomplete ig-like fold]]
[[Category: Structural protein/structural protein complex]]
[[Category: Structural protein/structural protein complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 24 09:32:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:46:43 2008''

Revision as of 09:46, 29 July 2008

Image:3bfw.png

Template:STRUCTURE 3bfw

Crystal structure of truncated FimG (FimGt) in complex with the donor strand peptide of FimF (DSF)

Template:ABSTRACT PUBMED 18400183

About this Structure

3BFW is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Infinite Kinetic Stability against Dissociation of Supramolecular Protein Complexes through Donor Strand Complementation., Puorger C, Eidam O, Capitani G, Erilov D, Grutter MG, Glockshuber R, Structure. 2008 Apr;16(4):631-42. PMID:18400183

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