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6n48
From Proteopedia
(Difference between revisions)
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<StructureSection load='6n48' size='340' side='right'caption='[[6n48]], [[Resolution|resolution]] 3.20Å' scene=''> | <StructureSection load='6n48' size='340' side='right'caption='[[6n48]], [[Resolution|resolution]] 3.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6n48]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[6n48]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Camelidae Camelidae], [https://en.wikipedia.org/wiki/Enterobacteria_phage_RB59 Enterobacteria phage RB59] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N48 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6N48 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1WV:(2S)-2,3-DIHYDROXYPROPYL+(7Z)-TETRADEC-7-ENOATE'>1WV</scene>, <scene name='pdbligand=KBY:N-[(3R)-4-(4-tert-butylphenyl)-3-({2-[(4-methoxyphenyl)sulfanyl]-5-[methyl(propan-2-yl)sulfamoyl]benzene-1-carbonyl}amino)butanoyl]glycine'>KBY</scene>, <scene name='pdbligand=P0G:8-[(1R)-2-{[1,1-DIMETHYL-2-(2-METHYLPHENYL)ETHYL]AMINO}-1-HYDROXYETHYL]-5-HYDROXY-2H-1,4-BENZOXAZIN-3(4H)-ONE'>P0G</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1WV:(2S)-2,3-DIHYDROXYPROPYL+(7Z)-TETRADEC-7-ENOATE'>1WV</scene>, <scene name='pdbligand=KBY:N-[(3R)-4-(4-tert-butylphenyl)-3-({2-[(4-methoxyphenyl)sulfanyl]-5-[methyl(propan-2-yl)sulfamoyl]benzene-1-carbonyl}amino)butanoyl]glycine'>KBY</scene>, <scene name='pdbligand=P0G:8-[(1R)-2-{[1,1-DIMETHYL-2-(2-METHYLPHENYL)ETHYL]AMINO}-1-HYDROXYETHYL]-5-HYDROXY-2H-1,4-BENZOXAZIN-3(4H)-ONE'>P0G</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6n48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n48 OCA], [https://pdbe.org/6n48 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6n48 RCSB], [https://www.ebi.ac.uk/pdbsum/6n48 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6n48 ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ADRB2_HUMAN ADRB2_HUMAN] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 6n48" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 6n48" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Adrenergic receptor 3D structures|Adrenergic receptor 3D structures]] | ||
| + | *[[Antibody 3D structures|Antibody 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Camelidae]] | [[Category: Camelidae]] | ||
| - | [[Category: | + | [[Category: Enterobacteria phage RB59]] |
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | + | [[Category: Ahn S]] | |
| - | [[Category: Ahn | + | [[Category: Hirata K]] |
| - | [[Category: Hirata | + | [[Category: Huang LY]] |
| - | [[Category: Huang | + | [[Category: Kahsai AW]] |
| - | [[Category: Kahsai | + | [[Category: Kobilka BK]] |
| - | [[Category: Kobilka | + | [[Category: Lefkowitz RJ]] |
| - | [[Category: Lefkowitz | + | [[Category: Liu X]] |
| - | [[Category: Liu | + | [[Category: Masoudi A]] |
| - | [[Category: Masoudi | + | [[Category: Pani B]] |
| - | [[Category: Pani | + | |
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Structure of beta2 adrenergic receptor bound to BI167107, Nanobody 6B9, and a positive allosteric modulator
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Categories: Camelidae | Enterobacteria phage RB59 | Homo sapiens | Large Structures | Ahn S | Hirata K | Huang LY | Kahsai AW | Kobilka BK | Lefkowitz RJ | Liu X | Masoudi A | Pani B
