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6oea

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Current revision (07:09, 11 October 2023) (edit) (undo)
 
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<StructureSection load='6oea' size='340' side='right'caption='[[6oea]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='6oea' size='340' side='right'caption='[[6oea]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6oea]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=6nlc 6nlc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OEA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OEA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6oea]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=6nlc 6nlc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OEA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6OEA FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HMCES, C3orf37, DC12, SRAPD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6oea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oea OCA], [http://pdbe.org/6oea PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6oea RCSB], [http://www.ebi.ac.uk/pdbsum/6oea PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6oea ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6oea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oea OCA], [https://pdbe.org/6oea PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6oea RCSB], [https://www.ebi.ac.uk/pdbsum/6oea PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6oea ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/HMCES_HUMAN HMCES_HUMAN]] Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells, suggesting that it acts as a specific reader of 5hmC in stem cells (By similarity). May act as a peptidase; experimental evidences are however required to confirm this prediction (PubMed:23945014).<ref>PMID:23945014</ref>
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[https://www.uniprot.org/uniprot/HMCES_HUMAN HMCES_HUMAN] Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells, suggesting that it acts as a specific reader of 5hmC in stem cells (By similarity). May act as a peptidase; experimental evidences are however required to confirm this prediction (PubMed:23945014).<ref>PMID:23945014</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Synthetic construct]]
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[[Category: Bountra, C]]
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[[Category: Arrowsmith CH]]
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[[Category: Edwards, A M]]
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[[Category: Bountra C]]
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[[Category: Halabelian, L]]
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[[Category: Edwards AM]]
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[[Category: Li, Y]]
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[[Category: Halabelian L]]
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[[Category: Ravichandran, M]]
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[[Category: Li Y]]
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[[Category: Structural genomic]]
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[[Category: Ravichandran M]]
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[[Category: Zeng, H]]
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[[Category: Zeng H]]
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[[Category: 3' overhang]]
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[[Category: Dna binding protein-dna complex]]
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[[Category: Dna damage protein]]
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[[Category: Dna-binding]]
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[[Category: Hmce]]
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[[Category: Protein-dna complex]]
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[[Category: Sgc]]
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[[Category: Srap domain]]
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Current revision

Crystal structure of HMCES SRAP domain in complex with longer 3' overhang DNA

PDB ID 6oea

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