4ymb

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<StructureSection load='4ymb' size='340' side='right'caption='[[4ymb]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
<StructureSection load='4ymb' size='340' side='right'caption='[[4ymb]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ymb]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YMB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YMB FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ymb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YMB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YMB FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4E7:(3R,4S)-3-(3-CARBOXYPHENYL)-4-PROPYL-L-PROLINE'>4E7</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4E7:(3R,4S)-3-(3-CARBOXYPHENYL)-4-PROPYL-L-PROLINE'>4E7</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4e0x|4e0x]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ymb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ymb OCA], [https://pdbe.org/4ymb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ymb RCSB], [https://www.ebi.ac.uk/pdbsum/4ymb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ymb ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ymb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ymb OCA], [http://pdbe.org/4ymb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ymb RCSB], [http://www.ebi.ac.uk/pdbsum/4ymb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ymb ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GRIK1_RAT GRIK1_RAT]] Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.<ref>PMID:16540562</ref>
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[https://www.uniprot.org/uniprot/GRIK1_RAT GRIK1_RAT] Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.<ref>PMID:16540562</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Ionotropic Glutamate Receptors|Ionotropic Glutamate Receptors]]
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*[[Glutamate receptor 3D structures|Glutamate receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Frydenvang, K]]
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[[Category: Rattus norvegicus]]
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[[Category: Kastrup, J S]]
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[[Category: Frydenvang K]]
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[[Category: Moller, C]]
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[[Category: Kastrup JS]]
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[[Category: Tapken, D]]
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[[Category: Moller C]]
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[[Category: Antagonist]]
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[[Category: Tapken D]]
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[[Category: Fusion protein]]
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[[Category: Ionotropic glutamate receptor]]
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[[Category: Kainate receptor gluk1]]
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[[Category: Ligand-binding domain]]
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[[Category: Signaling protein]]
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Revision as of 08:18, 3 May 2023

Structure of the ligand-binding domain of GluK1 in complex with the antagonist CNG10111

PDB ID 4ymb

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