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4yzy

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<StructureSection load='4yzy' size='340' side='right'caption='[[4yzy]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
<StructureSection load='4yzy' size='340' side='right'caption='[[4yzy]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4yzy]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YZY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YZY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4yzy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YZY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YZY FirstGlance]. <br>
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</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yzy OCA], [https://pdbe.org/4yzy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yzy RCSB], [https://www.ebi.ac.uk/pdbsum/4yzy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yzy ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yzy OCA], [http://pdbe.org/4yzy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yzy RCSB], [http://www.ebi.ac.uk/pdbsum/4yzy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yzy ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/E2AK3_MOUSE E2AK3_MOUSE]] Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1).<ref>PMID:11035797</ref>
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[https://www.uniprot.org/uniprot/E2AK3_MOUSE E2AK3_MOUSE] Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1).<ref>PMID:11035797</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Mus musculus]]
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[[Category: Ali, M M.U]]
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[[Category: Ali MMU]]
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[[Category: Carrara, M]]
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[[Category: Carrara M]]
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[[Category: Prischi, F]]
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[[Category: Prischi F]]
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[[Category: Dimer]]
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[[Category: Er stress sensing]]
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[[Category: Perk]]
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[[Category: Proteostasis]]
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[[Category: Signaling protein]]
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[[Category: Upr]]
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Revision as of 07:33, 10 May 2023

Crystal structures reveal transient PERK luminal domain tetramerization in ER stress signaling

PDB ID 4yzy

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