3bt2

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{{STRUCTURE_3bt2| PDB=3bt2 | SCENE= }}
{{STRUCTURE_3bt2| PDB=3bt2 | SCENE= }}
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'''Structure of urokinase receptor, urokinase and vitronectin complex'''
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===Structure of urokinase receptor, urokinase and vitronectin complex===
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==Overview==
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The urokinase receptor (uPAR) can recognize several ligands. The structural basis for this multiple ligand recognition by uPAR is unknown. This study reports the crystal structures of uPAR in complex with both urokinase (uPA) and vitronectin and reveal that uPA occupies the central cavity of the receptor, whereas vitronectin binds at the outer side of the receptor. These results provide a structural understanding of one receptor binding to two ligands.
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(as it appears on PubMed at http://www.pubmed.gov), where 18376415 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18376415}}
==Disease==
==Disease==
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[[Category: Sulfation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 24 09:33:48 2008''
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Revision as of 04:04, 29 July 2008

Image:3bt2.png

Template:STRUCTURE 3bt2

Contents

Structure of urokinase receptor, urokinase and vitronectin complex

Template:ABSTRACT PUBMED 18376415

Disease

Known disease associated with this structure: Alzheimer disease, late-onset, susceptibility to OMIM:[191840]

About this Structure

3BT2 is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes., Huai Q, Zhou A, Lin L, Mazar AP, Parry GC, Callahan J, Shaw DE, Furie B, Furie BC, Huang M, Nat Struct Mol Biol. 2008 Apr;15(4):422-3. Epub 2008 Mar 23. PMID:18376415

Page seeded by OCA on Tue Jul 29 07:04:05 2008

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