1iva

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<StructureSection load='1iva' size='340' side='right'caption='[[1iva]], [[NMR_Ensembles_of_Models | 16 NMR models]]' scene=''>
<StructureSection load='1iva' size='340' side='right'caption='[[1iva]], [[NMR_Ensembles_of_Models | 16 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1iva]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ageap Ageap]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IVA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IVA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1iva]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ageap Ageap]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IVA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IVA FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1iva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iva OCA], [http://pdbe.org/1iva PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1iva RCSB], [http://www.ebi.ac.uk/pdbsum/1iva PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1iva ProSAT]</span></td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1iva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iva OCA], [https://pdbe.org/1iva PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1iva RCSB], [https://www.ebi.ac.uk/pdbsum/1iva PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1iva ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TOG4A_AGEAP TOG4A_AGEAP]] Omega-agatoxins inhibit neuronal voltage-gated calcium channels. This toxin acts by modifying the gating of the high voltage activated P-type Cav2.1/CACNA1A channel. Is a potent blocker in both insect and mammalian central neurons.<ref>PMID:1311418</ref> <ref>PMID:8250902</ref> <ref>PMID:7898748</ref> <ref>PMID:9129813</ref> <ref>PMID:9120560</ref> <ref>PMID:11055992</ref> <ref>PMID:11522785</ref>
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[[https://www.uniprot.org/uniprot/TOG4A_AGEAP TOG4A_AGEAP]] Omega-agatoxins inhibit neuronal voltage-gated calcium channels. This toxin acts by modifying the gating of the high voltage activated P-type Cav2.1/CACNA1A channel. Is a potent blocker in both insect and mammalian central neurons.<ref>PMID:1311418</ref> <ref>PMID:8250902</ref> <ref>PMID:7898748</ref> <ref>PMID:9129813</ref> <ref>PMID:9120560</ref> <ref>PMID:11055992</ref> <ref>PMID:11522785</ref>
== References ==
== References ==
<references/>
<references/>

Revision as of 07:14, 14 April 2021

STRUCTURE-ACTIVITY RELATIONSHIPS FOR P-TYPE CALCIUM CHANNEL SELECTIVE OMEGA-AGATOXINS

PDB ID 1iva

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