Matriptase
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
ST14 active site has the conformation of a typical serine protease like trypsin or chymotrypsin with the <scene name='59/595760/Cv/5'>Ser-His-Asp catalytic triad</scene> and <scene name='59/595760/Cv/6'>Gly-Ser oxyanion hole</scene>. The <scene name='59/595760/Cv/7'>inhibitor benzamidine blocks the catalytic triad</scene><ref>PMID:11696548</ref>. Water molecules shown as red spheres. | ST14 active site has the conformation of a typical serine protease like trypsin or chymotrypsin with the <scene name='59/595760/Cv/5'>Ser-His-Asp catalytic triad</scene> and <scene name='59/595760/Cv/6'>Gly-Ser oxyanion hole</scene>. The <scene name='59/595760/Cv/7'>inhibitor benzamidine blocks the catalytic triad</scene><ref>PMID:11696548</ref>. Water molecules shown as red spheres. | ||
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| + | == 3D Structures of matriptase == | ||
| + | [[Matriptase 3D structures]] | ||
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</StructureSection> | </StructureSection> | ||
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*'''matriptase''' | *'''matriptase''' | ||
| - | **[[4is5]] – hST14 catalytic domain - human<br /> | + | **[[4is5]], [[5lyo]] – hST14 catalytic domain - human<br /> |
*Matriptase complex with small molecule inhibitor | *Matriptase complex with small molecule inhibitor | ||
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**[[4o97]], [[4o9v]] – hST14 catalytic domain + benzamidine derivative + tetrapeptide<br /> | **[[4o97]], [[4o9v]] – hST14 catalytic domain + benzamidine derivative + tetrapeptide<br /> | ||
**[[3ncl]] – hST14 catalytic domain (mutant) + benzamidine derivative<br /> | **[[3ncl]] – hST14 catalytic domain (mutant) + benzamidine derivative<br /> | ||
| - | **[[2gv7]], [[4jz1]], [[4jzi]], [[4jyt]] – hST14 catalytic domain + inhibitor<br /> | + | **[[2gv7]], [[4jz1]], [[4jzi]], [[4jyt]], [[4r0i]] – hST14 catalytic domain + inhibitor<br /> |
| + | **[[6n4t]] – hST14 catalytic domain + benzothiazole derivative<br /> | ||
*Matriptase complex with polypeptide inhibitor | *Matriptase complex with polypeptide inhibitor | ||
Revision as of 10:41, 28 October 2019
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3D Structures of matriptase
Updated on 28-October-2019
References
- ↑ List K, Bugge TH, Szabo R. Matriptase: potent proteolysis on the cell surface. Mol Med. 2006 Jan-Mar;12(1-3):1-7. PMID:16838070 doi:http://dx.doi.org/10.2119/2006-00022.List
- ↑ Johnson MD, Oberst MD, Lin CY, Dickson RB. Possible role of matriptase in the diagnosis of ovarian cancer. Expert Rev Mol Diagn. 2003 May;3(3):331-8. PMID:12779007 doi:http://dx.doi.org/10.1586/14737159.3.3.331
- ↑ Chen CJ, Wu BY, Tsao PI, Chen CY, Wu MH, Chan YL, Lee HS, Johnson MD, Eckert RL, Chen YW, Chou F, Wang JK, Lin CY. Increased matriptase zymogen activation in inflammatory skin disorders. Am J Physiol Cell Physiol. 2011 Mar;300(3):C406-15. doi:, 10.1152/ajpcell.00403.2010. Epub 2010 Dec 1. PMID:21123732 doi:http://dx.doi.org/10.1152/ajpcell.00403.2010
- ↑ Friedrich R, Fuentes-Prior P, Ong E, Coombs G, Hunter M, Oehler R, Pierson D, Gonzalez R, Huber R, Bode W, Madison EL. Catalytic domain structures of MT-SP1/matriptase, a matrix-degrading transmembrane serine proteinase. J Biol Chem. 2002 Jan 18;277(3):2160-8. Epub 2001 Nov 5. PMID:11696548 doi:10.1074/jbc.M109830200
