3bxj

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{{STRUCTURE_3bxj| PDB=3bxj | SCENE= }}
{{STRUCTURE_3bxj| PDB=3bxj | SCENE= }}
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'''Crystal Structure of the C2-GAP Fragment of synGAP'''
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===Crystal Structure of the C2-GAP Fragment of synGAP===
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==Overview==
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The brain-specific synaptic guanosine triphosphatase (GTPase)-activating protein (SynGAP) is important in synaptic plasticity. It shows dual specificity for the small guanine nucleotide-binding proteins Rap and Ras. Here, we show that RapGAP activity of SynGAP requires its C2 domain. In contrast to the isolated GAP domain, which does not show any detectable RapGAP activity, a fragment comprising the C2 and GAP domains (C2-GAP) stimulates the intrinsic GTPase reaction of Rap by approximately 1 x 10(4). The C2-GAP crystal structure, complemented by modelling and biochemical analyses, favours a concerted movement of the C2 domain towards the switch II region of Rap to assist in GTPase stimulation. Our data support a catalytic mechanism similar to that of canonical RasGAPs and distinct from the canonical RapGAPs. SynGAP presents the first example, to our knowledge, of a GAP that uses a second domain for catalytic activity, thus pointing to a new function of C2 domains.
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(as it appears on PubMed at http://www.pubmed.gov), where 18323856 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18323856}}
==About this Structure==
==About this Structure==
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[[Category: Sh3-binding]]
[[Category: Sh3-binding]]
[[Category: Signaling protein]]
[[Category: Signaling protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 24 09:34:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:46:27 2008''

Revision as of 03:46, 29 July 2008

Image:3bxj.png

Template:STRUCTURE 3bxj

Crystal Structure of the C2-GAP Fragment of synGAP

Template:ABSTRACT PUBMED 18323856

About this Structure

3BXJ is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

The C2 domain of SynGAP is essential for stimulation of the Rap GTPase reaction., Pena V, Hothorn M, Eberth A, Kaschau N, Parret A, Gremer L, Bonneau F, Ahmadian MR, Scheffzek K, EMBO Rep. 2008 Mar 7;. PMID:18323856

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