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Metabotropic glutamate receptor
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<scene name='46/464134/Cv/3'>Glutamate is bound to GluR1</scene> in the crevice between the N-terminal and C-terminal domains<ref>PMID:11069170</ref>. Water molecules are shown as red spheres. | <scene name='46/464134/Cv/3'>Glutamate is bound to GluR1</scene> in the crevice between the N-terminal and C-terminal domains<ref>PMID:11069170</ref>. Water molecules are shown as red spheres. | ||
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| + | ==3D structures of metabotropic glutamate receptor == | ||
| + | [[Metabotropic glutamate receptor 3D structures]] | ||
</StructureSection> | </StructureSection> | ||
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*Metabotropic glutamate receptor 1 | *Metabotropic glutamate receptor 1 | ||
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| - | + | ||
**[[3ks9]] – hMGluR1 (mutant) + antagonist - human<br /> | **[[3ks9]] – hMGluR1 (mutant) + antagonist - human<br /> | ||
**[[4or2]] - hMGluR1/cytochrome b526<br /> | **[[4or2]] - hMGluR1/cytochrome b526<br /> | ||
| + | **[[1ewt]], [[1ewv]] - rMGluR1 LBD - rat<br /> | ||
**[[1isr]], [[1ewk]] – rMGluR1 LBD + Glu<br /> | **[[1isr]], [[1ewk]] – rMGluR1 LBD + Glu<br /> | ||
**[[1iss]] - rMGluR1 LBD + antagonist<br /> | **[[1iss]] - rMGluR1 LBD + antagonist<br /> | ||
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**[[5cnk]] – hMGluR3 LBD + Glu <br /> | **[[5cnk]] – hMGluR3 LBD + Glu <br /> | ||
| - | **[[2e4u]] – rMGluR3 LBD (mutant) + Glu<br /> | ||
| - | **[[2e4v]], [[2e4w]], [[2e4x]], [[2e4y]], [[2e4z]] - rMGluR3 LBD (mutant) + agonist<br /> | ||
**[[3sm9]] - hMGluR3 + antagonist<br /> | **[[3sm9]] - hMGluR3 + antagonist<br /> | ||
**[[4xar]], [[6b7h]] – hMGluR3 LBD + agonist<br /> | **[[4xar]], [[6b7h]] – hMGluR3 LBD + agonist<br /> | ||
**[[5cnm]] – hMGluR3 LBD + Glu analog<br /> | **[[5cnm]] – hMGluR3 LBD + Glu analog<br /> | ||
| + | **[[2e4u]] – rMGluR3 LBD (mutant) + Glu<br /> | ||
| + | **[[2e4v]], [[2e4w]], [[2e4x]], [[2e4y]], [[2e4z]] - rMGluR3 LBD (mutant) + agonist<br /> | ||
*Metabotropic glutamate receptor 5 | *Metabotropic glutamate receptor 5 | ||
| + | **[[6n52]] – hMGluR5 – Cryo EM<br /> | ||
| + | **[[6n51]], [[6n50]], [[6n4y]] – hMGluR5 + nanobody – Cryo EM<br /> | ||
| + | **[[6n4x]] – hMGluR5 LBD<br /> | ||
**[[6ffh]], [[6ffi]] - hMGluR5 LBD (mutant) + positive allosteric modulator<br /> | **[[6ffh]], [[6ffi]] - hMGluR5 LBD (mutant) + positive allosteric modulator<br /> | ||
**[[3lmk]] – hMGluR5 LBD (mutant) + positive allosteric modulator + Glu<br /> | **[[3lmk]] – hMGluR5 LBD (mutant) + positive allosteric modulator + Glu<br /> | ||
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**[[6bsz]] – hMGluR8 LBD + Glu <br /> | **[[6bsz]] – hMGluR8 LBD + Glu <br /> | ||
**[[6bt5]] – hMGluR8 LBD + phosphonobutanoic acid <br /> | **[[6bt5]] – hMGluR8 LBD + phosphonobutanoic acid <br /> | ||
| + | **[[6e5v]] – hMGluR8 N-terminal (mutant) + inhibitor <br /> | ||
}} | }} | ||
==See Also== | ==See Also== | ||
Revision as of 09:01, 30 October 2019
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3D structures of metabotropic glutamate receptor
Updated on 30-October-2019
See Also
Membrane Channels & Pumps
Ionotropic_Glutamate_Receptors
Alzheimer's Disease
References
- ↑ Traynelis SF, Wollmuth LP, McBain CJ, Menniti FS, Vance KM, Ogden KK, Hansen KB, Yuan H, Myers SJ, Dingledine R. Glutamate receptor ion channels: structure, regulation, and function. Pharmacol Rev. 2010 Sep;62(3):405-96. doi: 10.1124/pr.109.002451. PMID:20716669 doi:http://dx.doi.org/10.1124/pr.109.002451
- ↑ Johnson KA, Conn PJ, Niswender CM. Glutamate receptors as therapeutic targets for Parkinson's disease. CNS Neurol Disord Drug Targets. 2009 Dec;8(6):475-91. PMID:19702565
- ↑ Niswender CM, Conn PJ. Metabotropic glutamate receptors: physiology, pharmacology, and disease. Annu Rev Pharmacol Toxicol. 2010;50:295-322. doi:, 10.1146/annurev.pharmtox.011008.145533. PMID:20055706 doi:http://dx.doi.org/10.1146/annurev.pharmtox.011008.145533
- ↑ Kunishima N, Shimada Y, Tsuji Y, Sato T, Yamamoto M, Kumasaka T, Nakanishi S, Jingami H, Morikawa K. Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor. Nature. 2000 Oct 26;407(6807):971-7. PMID:11069170 doi:10.1038/35039564
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