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Glycoprotein GP

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== Function ==
== Function ==
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The virus contains a surface '''glycoprotein PG''' that is responsible for binding to target cells and subsequent fusion of viral and host-cell membranes. GP is expressed as a single-chain precursor that is posttranslationally processed into disulfide-linked fragments of '''GP1''' and '''GP2''' <ref>PMID:10077567</ref>. Viral infections is initiated by interactions between the viral protein glycoprotein PG1 and its cognate receptor. The GP2 subunit is thought to mediate membrane fusion.
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The virus contains a surface '''glycoprotein GP''' or '''envelope glycoprotein GP''' that is responsible for binding to target cells and subsequent fusion of viral and host-cell membranes. GP is expressed as a single-chain precursor that is posttranslationally processed into disulfide-linked fragments of '''GP1''' and '''GP2''' <ref>PMID:10077567</ref>. Viral infections is initiated by interactions between the viral protein glycoprotein PG1 and its cognate receptor. The GP2 subunit is thought to mediate membrane fusion.
For details see [[GP1 of Lassa Virus]].
For details see [[GP1 of Lassa Virus]].

Current revision

Ebolavirus glycosylated GP1 (wheat) and GP2 (blue) complex with antibody heavy chain (red) and light chain (aqua) (PDB code 3s88)

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References

  1. ↑ Malashkevich VN, Schneider BJ, McNally ML, Milhollen MA, Pang JX, Kim PS. Core structure of the envelope glycoprotein GP2 from Ebola virus at 1.9-A resolution. Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2662-7. PMID:10077567

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

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