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2jqt

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{{STRUCTURE_2jqt| PDB=2jqt | SCENE= }}
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'''Structure of the bacterial replication origin-associated protein Cnu'''
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===Structure of the bacterial replication origin-associated protein Cnu===
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==Overview==
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Cnu is a nucleoid protein that has a high degree of sequence homology with Hha/YmoA family proteins, which bind to chromatin and regulate the expression of Escherichia coli virulence genes in response to changes in temperature or ionic strength. Here, we determined its solution structure and dynamic properties and mapped H-NS binding sites. Cnu consists of three alpha helices that are comparable with those of Hha, but it has significant flexibility in the C-terminal region and lacks a short alpha helix present in Hha. Upon increasing ionic strength, the helical structure of Cnu is destabilized, especially at the ends of the helices. The dominant H-NS binding sites, located at helix 3 as in Hha, reveal a common structural platform for H-NS binding. Our results may provide structural and dynamic bases for the similarity and dissimilarity between Cnu and Hha functions.
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(as it appears on PubMed at http://www.pubmed.gov), where 18189420 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18189420}}
==About this Structure==
==About this Structure==
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2JQT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JQT OCA].
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2JQT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JQT OCA].
==Reference==
==Reference==
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[[Category: Replication origin associated]]
[[Category: Replication origin associated]]
[[Category: Ydgt]]
[[Category: Ydgt]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 24 09:37:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:33:39 2008''

Revision as of 13:33, 27 July 2008

Image:2jqt.png

Template:STRUCTURE 2jqt

Structure of the bacterial replication origin-associated protein Cnu

Template:ABSTRACT PUBMED 18189420

About this Structure

2JQT is a Single protein structure of sequence from Escherichia coli. Full experimental information is available from OCA.

Reference

Structure of the nucleoid-associated protein Cnu reveals common binding sites for H-NS in Cnu and Hha., Bae SH, Liu D, Lim HM, Lee Y, Choi BS, Biochemistry. 2008 Feb 19;47(7):1993-2001. Epub 2008 Jan 12. PMID:18189420

Page seeded by OCA on Sun Jul 27 16:33:39 2008

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