6s8l
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure, Thermodynamics, and Kinetics of Plinabulin Binding to two Tubulin Isotypes== | |
| - | + | <StructureSection load='6s8l' size='340' side='right'caption='[[6s8l]], [[Resolution|resolution]] 1.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6s8l]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S8L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6S8L FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PN6:(3Z,6Z)-3-BENZYLIDENE-6-[(5-TERT-BUTYL-1H-IMIDAZOL-4-YL)METHYLIDENE]PIPERAZINE-2,5-DIONE'>PN6</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6s8l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s8l OCA], [http://pdbe.org/6s8l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6s8l RCSB], [http://www.ebi.ac.uk/pdbsum/6s8l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6s8l ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/TBB3_HUMAN TBB3_HUMAN]] Congenital fibrosis of extraocular muscles;Cortical dysgenesis with pontocerebellar hypoplasia due to TUBB3 mutation. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TBA1B_HUMAN TBA1B_HUMAN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/TBB3_HUMAN TBB3_HUMAN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB3 plays a critical role in proper axon guidance and mantainance.<ref>PMID:20074521</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Olieric, N]] | [[Category: Olieric, N]] | ||
[[Category: Sharma, A]] | [[Category: Sharma, A]] | ||
| + | [[Category: Steinmetz, M]] | ||
| + | [[Category: Cancer]] | ||
| + | [[Category: Microtubule]] | ||
| + | [[Category: Microtubule targeting agent]] | ||
| + | [[Category: Structural protein]] | ||
| + | [[Category: Tubulin]] | ||
Current revision
Structure, Thermodynamics, and Kinetics of Plinabulin Binding to two Tubulin Isotypes
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