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6s8y
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of cytochrome c in complex with a sulfonated quinoline-derived foldamer== | |
| + | <StructureSection load='6s8y' size='340' side='right'caption='[[6s8y]], [[Resolution|resolution]] 2.09Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6s8y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S8Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6S8Y FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.09Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene>, <scene name='pdbligand=L0T:8-acetamido-2-[[2-[[2-[[2-[[2-[[2-[[2-[(2-carboxy-4-sulfonato-quinolin-8-yl)carbamoyl]-4-sulfonato-quinolin-8-yl]carbamoyl]-4-sulfonato-quinolin-8-yl]carbamoyl]-4-sulfonato-quinolin-8-yl]carbamoyl]-4-sulfonato-quinolin-8-yl]carbamoyl]-4-sulfonato-quinolin-8-yl]carbamoyl]-4-sulfonato-quinolin-8-yl]carbamoyl]quinoline-4-sulfonate'>L0T</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6s8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s8y OCA], [https://pdbe.org/6s8y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6s8y RCSB], [https://www.ebi.ac.uk/pdbsum/6s8y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6s8y ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CYC1_YEAST CYC1_YEAST] Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Co-crystallization of a 2 kDa tether-free sulfonated foldamer and the 13 kDa lysine-rich cytochrome c yielded a remarkable biohybrid assembly with chiral resolution of the foldamer helix handedness. In the crystal a approximately 5 nm foldamer stack was surrounded by eight molecules of protein. NMR and CD experiments suggest interesting differences in the solution state recognition processes. | ||
| - | + | Crystal structure of a protein-aromatic foldamer composite: macromolecular chiral resolution.,Alex JM, Corvaglia V, Hu X, Engilberge S, Huc I, Crowley PB Chem Commun (Camb). 2019 Sep 21;55(74):11087-11090. doi: 10.1039/c9cc05330a. Epub , 2019 Aug 28. PMID:31460523<ref>PMID:31460523</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 6s8y" style="background-color:#fffaf0;"></div> |
| - | [[Category: Corvaglia | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Large Structures]] |
| + | [[Category: Saccharomyces cerevisiae]] | ||
| + | [[Category: Alex JM]] | ||
| + | [[Category: Corvaglia V]] | ||
| + | [[Category: Crowley PB]] | ||
| + | [[Category: Engilberge S]] | ||
| + | [[Category: Hu X]] | ||
| + | [[Category: Huc I]] | ||
Current revision
Crystal structure of cytochrome c in complex with a sulfonated quinoline-derived foldamer
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