2spc

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<StructureSection load='2spc' size='340' side='right'caption='[[2spc]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='2spc' size='340' side='right'caption='[[2spc]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2spc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2SPC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2SPC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2spc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2SPC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2SPC FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2spc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2spc OCA], [http://pdbe.org/2spc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2spc RCSB], [http://www.ebi.ac.uk/pdbsum/2spc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2spc ProSAT]</span></td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2spc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2spc OCA], [https://pdbe.org/2spc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2spc RCSB], [https://www.ebi.ac.uk/pdbsum/2spc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2spc ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SPTCA_DROME SPTCA_DROME]] Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. Essential for larval survival and development. Stabilizes cell to cell interactions that are critical for the maintenance of cell shape and subcellular organization within embryonic tissues. Lva and spectrin may form a Golgi-based scaffold that mediates interaction of Golgi bodies with microtubules and facilitates Golgi-derived membrane secretion required for the formation of furrows during cellularization.<ref>PMID:8276898</ref> <ref>PMID:3680372</ref> <ref>PMID:11076973</ref>
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[[https://www.uniprot.org/uniprot/SPTCA_DROME SPTCA_DROME]] Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. Essential for larval survival and development. Stabilizes cell to cell interactions that are critical for the maintenance of cell shape and subcellular organization within embryonic tissues. Lva and spectrin may form a Golgi-based scaffold that mediates interaction of Golgi bodies with microtubules and facilitates Golgi-derived membrane secretion required for the formation of furrows during cellularization.<ref>PMID:8276898</ref> <ref>PMID:3680372</ref> <ref>PMID:11076973</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]

Revision as of 10:37, 7 July 2021

CRYSTAL STRUCTURE OF THE REPETITIVE SEGMENTS OF SPECTRIN

PDB ID 2spc

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