1wu3

From Proteopedia

(Difference between revisions)

Revision as of 09:04, 21 April 2021

Crystal structure of recombinant murine interferon beta

Structural highlights

1wu3 is a 1 chain structure with sequence from Lk3 transgenic mice. This structure supersedes the now removed PDB entry 1rmi. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[IFNB_MOUSE] Has antiviral, antibacterial and anticancer activities.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The crystal structure of recombinant murine interferon-beta (reMuIFN-beta) has been refined at 2.15 A resolution using newly collected synchrotron data. Based on 11,228 reflections (8.0 to 2.15 A), a final R-factor of 19.1% (with a free R-factor of 25.8%) was obtained with a model obeying standard geometry within 0.013 A in bond lengths and 1.4 degrees in bond angles. Compared with the previously reported model, several amino acid residues in helix A are frame-shifted, the conformations are changed for parts of loops AB and BC, helix C is extended and a new short helix exists in loop CD. Evolutionary considerations taken together, the type I interferons appear to share common structural features with respect to the chain-folding topology and the hydrogen-bond networks between various polypeptide segments. Specifically, the disposition of the C-terminal segment of loop AB (after Arg33), known to be an important receptor-binding site, seems to be strictly maintained among the type I interferons. The exposed amino acid residues on helices A and C, which have recently been implicated as the binding site for another receptor molecule, are less well conserved. This may be responsible for varied cellular effects among the subtypes of type I interferons.

Refined crystal structure of recombinant murine interferon-beta at 2.15 A resolution.,Senda T, Saitoh S, Mitsui Y J Mol Biol. 1995 Oct 13;253(1):187-207. PMID:7473712^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Senda T, Saitoh S, Mitsui Y. Refined crystal structure of recombinant murine interferon-beta at 2.15 A resolution. J Mol Biol. 1995 Oct 13;253(1):187-207. PMID:7473712

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1wu3"

@@ Line 3: / Line 3: @@
 <StructureSection load='1wu3' size='340' side='right'caption='[[1wu3]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1wu3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1rmi 1rmi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WU3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WU3 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1wu3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1rmi 1rmi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WU3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WU3 FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wu3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wu3 OCA], [http://pdbe.org/1wu3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wu3 RCSB], [http://www.ebi.ac.uk/pdbsum/1wu3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wu3 ProSAT]</span></td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wu3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wu3 OCA], [https://pdbe.org/1wu3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wu3 RCSB], [https://www.ebi.ac.uk/pdbsum/1wu3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wu3 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/IFNB_MOUSE IFNB_MOUSE]] Has antiviral, antibacterial and anticancer activities.
+[[https://www.uniprot.org/uniprot/IFNB_MOUSE IFNB_MOUSE]] Has antiviral, antibacterial and anticancer activities.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 29: / Line 29: @@
 ==See Also==
-*[[Interferon|Interferon]]
+*[[Interferon 3D structures|Interferon 3D structures]]
 *[[Multiple sclerosis|Multiple sclerosis]]
 == References ==

1wu3

From Proteopedia

Revision as of 09:04, 21 April 2021

Crystal structure of recombinant murine interferon beta

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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