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1szi

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Revision as of 09:02, 21 April 2021

Crystal Structure of the C-terminus of TIP47

Structural highlights

1szi is a 1 chain structure with sequence from Lk3 transgenic mice. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[PLIN3_MOUSE] Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The perilipin/ADRP/TIP47 (PAT) proteins localize to the surface of intracellular neutral lipid droplets. Perilipin is essential for lipid storage and hormone regulated lipolysis in adipocytes, and perilipin null mice exhibit a dramatic reduction in adipocyte lipid stores. A significant fraction of the approximately 200 amino acid N-terminal region of the PAT proteins consists of 11-mer helical repeats that are also found in apolipoproteins and other lipid-associated proteins. The C-terminal 60% of TIP47, a representative PAT protein, comprises a monomeric and independently folded unit. The crystal structure of the C-terminal portion of TIP47 was determined and refined at 2.8 A resolution. The structure consists of an alpha/beta domain of novel topology and a four-helix bundle resembling the LDL receptor binding domain of apolipoprotein E. The structure suggests an analogy between PAT proteins and apolipoproteins in which helical repeats interact with lipid while the ordered C-terminal region is involved in protein:protein interactions.

Structure of a lipid droplet protein; the PAT family member TIP47.,Hickenbottom SJ, Kimmel AR, Londos C, Hurley JH Structure. 2004 Jul;12(7):1199-207. PMID:15242596^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Hickenbottom SJ, Kimmel AR, Londos C, Hurley JH. Structure of a lipid droplet protein; the PAT family member TIP47. Structure. 2004 Jul;12(7):1199-207. PMID:15242596 doi:10.1016/j.str.2004.04.021

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1szi"

@@ Line 3: / Line 3: @@
 <StructureSection load='1szi' size='340' side='right'caption='[[1szi]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1szi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SZI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SZI FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1szi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SZI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SZI FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1szi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1szi OCA], [http://pdbe.org/1szi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1szi RCSB], [http://www.ebi.ac.uk/pdbsum/1szi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1szi ProSAT]</span></td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1szi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1szi OCA], [https://pdbe.org/1szi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1szi RCSB], [https://www.ebi.ac.uk/pdbsum/1szi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1szi ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/PLIN3_MOUSE PLIN3_MOUSE]] Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (By similarity).
+[[https://www.uniprot.org/uniprot/PLIN3_MOUSE PLIN3_MOUSE]] Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (By similarity).
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]

1szi

From Proteopedia

Revision as of 09:02, 21 April 2021

Crystal Structure of the C-terminus of TIP47

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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