Neuraminidase

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== Structural highlights ==
== Structural highlights ==
The biological assembly of H5N1 avian influenza virus neuraminidase is <scene name='35/352656/Cv/5'>homotetramer</scene>. The <scene name='35/352656/Cv/6'>active site of NAN contains the influenza drug Tamiflu</scene><ref>PMID:16915235</ref>.
The biological assembly of H5N1 avian influenza virus neuraminidase is <scene name='35/352656/Cv/5'>homotetramer</scene>. The <scene name='35/352656/Cv/6'>active site of NAN contains the influenza drug Tamiflu</scene><ref>PMID:16915235</ref>.
 +
 +
==3D structures of Neuraminidase==
 +
[[Neuraminidase 3D structures]]
 +
</StructureSection>
</StructureSection>
==3D structures of Neuraminidase==
==3D structures of Neuraminidase==
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**[[4fvk]], [[4gez]] - IvNANA residues 76-442<br />
**[[4fvk]], [[4gez]] - IvNANA residues 76-442<br />
**[[3k38]], [[4hzy]] – IvNANA (mutant) <br />
**[[3k38]], [[4hzy]] – IvNANA (mutant) <br />
-
**[[4gzo]], [[4k1h]], [[4k1i]], [[4k1k]] - IvNAN N2 residues 77-469<br />
+
**[[4b7m]], [[6d96]] - IvNAN H1n1<br />
-
**[[4gzs]], [[4k1j]] - IvNAN N2 residues 77-469 (mutant)<br />
+
**[[6n4d]] – IvNAN H3n2<br />
-
**[[2ht5]] – IvNAN N8 residues 82-469<br />
+
-
**[[2htv]] - IvNAN N4 residues 82-469<br />
+
-
**[[2hty]] - IvNAN N1 residues 82-469<br />
+
-
**[[2qwa]] - IvNAN N9 Tern (mutant)<br />
+
-
**[[4b7m]] - IvNAN H1n1<br />
+
**[[4qn4]] – IvNAN H3n6<br />
**[[4qn4]] – IvNAN H3n6<br />
**[[4wa3]] – IvNAN H3n8<br />
**[[4wa3]] – IvNAN H3n8<br />
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**[[5l14]], [[3nn9]], [[4nn9]], [[5nn9]], [[6nn9]], [[4mwj]], [[4mwl]] – IvNAN H7n9<br />
**[[5l14]], [[3nn9]], [[4nn9]], [[5nn9]], [[6nn9]], [[4mwj]], [[4mwl]] – IvNAN H7n9<br />
**[[4qn3]] – IvNAN H10n7<br />
**[[4qn3]] – IvNAN H10n7<br />
-
**[[7nn9]] - IvNAN H11n9 Tern<br />
+
**[[7nn9]], [[6mcx]] - IvNAN H11n9 Tern<br />
**[[3sal]] - IvNAN H12n5 residues 82-469<br />
**[[3sal]] - IvNAN H12n5 residues 82-469<br />
**[[4gdi]], [[4gdj]] - IvNAN H17n10<br />
**[[4gdi]], [[4gdj]] - IvNAN H17n10<br />
**[[4mc7]] – IvNAN H18n11<br />
**[[4mc7]] – IvNAN H18n11<br />
 +
**[[2hty]] - IvNAN N1 residues 82-469<br />
 +
**[[4gzo]], [[4k1h]], [[4k1i]], [[4k1k]] - IvNAN N2 residues 77-469<br />
 +
**[[4gzs]], [[4k1j]] - IvNAN N2 residues 77-469 (mutant)<br />
 +
**[[2htv]] - IvNAN N4 residues 82-469<br />
 +
**[[6hgb]] – IvNAN N6<br />
 +
**[[2ht5]] – IvNAN N8 residues 82-469<br />
 +
**[[2qwa]] - IvNAN N9 Tern (mutant)<br />
*Binary complexes of Influenza virus neuraminidase
*Binary complexes of Influenza virus neuraminidase
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**[[3k39]], [[3k3a]], [[3ckz]], [[3cl0]], [[3cl2]], [[1l7g]], [[1l7h]] - IvNANA (mutant) + inhibitor<br />
**[[3k39]], [[3k3a]], [[3ckz]], [[3cl0]], [[3cl2]], [[1l7g]], [[1l7h]] - IvNANA (mutant) + inhibitor<br />
**[[1f8b]], [[1inv]], [[1inw]], [[1inx]], [[1iny]], [[4gb1]] – IvNANA + sialic acid analog<br />
**[[1f8b]], [[1inv]], [[1inw]], [[1inx]], [[1iny]], [[4gb1]] – IvNANA + sialic acid analog<br />
-
**[[3ti3]], [[3ti4]], [[3ti5]], [[3ti6]] – IvNAN H1n1 + inhibitor<br />
+
**[[3ti3]], [[3ti4]], [[3ti5]], [[3ti6]], [[6g02]], [[6g01]] - IvNAN H1n1 + inhibitor<br />
-
**[[4b7j]], [[4b7n]], [[4b7q]], [[4b7r]], [[5nzn]] - IvNAN H1n1 + drug<br />
+
**[[4qnp]], [[6q23]] - IvNAN H1n1 + antibody<br />
-
**[[4qnp]] - IvNAN H1n1 + antibody<br />
+
-
**[[5nzf]], [[5nze]], [[5nz4]], [[5nwe]] - IvNAN H1n1 (mutant) + drug<br />
+
**[[3tia]], [[3tib]], [[3tic]] – IvNAN H2n2 + inhibitor<br />
**[[3tia]], [[3tib]], [[3tic]] – IvNAN H2n2 + inhibitor<br />
 +
**[[6q20]] - IvNAN H2n2 + antibody<br />
 +
**[[6n6b]] - IvNAN H3n2 + antibody<br />
**[[2bat]], [[4gzw]], [[4gzx]], [[4gzq]] – IvNAN H3n2 + sialic acid<br />
**[[2bat]], [[4gzw]], [[4gzx]], [[4gzq]] – IvNAN H3n2 + sialic acid<br />
-
**[[4gzp]], [[4gzt]], [[6br6]], [[6br5]] - IvNAN H3n2 + drug<br />
 
-
**[[4qn6]] - IvNAN H3n6 + drug<br />
 
-
**[[4wa5]], [[4wa4]] - IvNAN H3n8 + drug<br />
 
**[[2ht7]], [[2ht8]], [[2htq]], [[2htu]] – IvNAN H5n1 + inhibitor<br />
**[[2ht7]], [[2ht8]], [[2htq]], [[2htu]] – IvNAN H5n1 + inhibitor<br />
-
**[[2htr]], [[2htw]] – IvNAN H5n1 + sialic acid analog<br />
+
**[[2htr]], [[2htw]] – IvNAN H5n1 + sialic acid analog<br /
-
**[[5l15]], [[5l17]], [[5jyy]], [[4mwq]], [[4mwr]], [[4mwu]], [[4mwv]], [[4mww]], [[4mwx]], [[4mwy]], [[4mx0]] - IvNAN H7n9 + drug<br />
+
**[[5l18]] - IvNAN H7n9 + sialic acid<br />
**[[5l18]] - IvNAN H7n9 + sialic acid<br />
-
**[[4mwq]], [[4mwr]], [[4mwu]], [[4mwv]], [[4mww]], [[4mwx]], [[4mwy]], [[4mx0]] - IvNAN H7n9 + flu drug<br />
+
**[[6q1z]] - IvNAN H7n9 + antibody<br />
-
**[[4qn7]]- IvNAN H10n7 + drug<br />
+
**[[1nna]], [[1nnb]], [[5w2y]], [[5w2w]], [[5w2u]], [[5w26]] - IvNAN H11n9 + neuraminic acid derivative<br />
**[[1nna]], [[1nnb]], [[5w2y]], [[5w2w]], [[5w2u]], [[5w26]] - IvNAN H11n9 + neuraminic acid derivative<br />
**[[4dgr]] - IvNAN H11n9 + benzoic acid derivative<br />
**[[4dgr]] - IvNAN H11n9 + benzoic acid derivative<br />
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**[[1xoe]], [[1xog]], [[3w09]] - IvNAN H11n9 Tern + inhibitor<br />
**[[1xoe]], [[1xog]], [[3w09]] - IvNAN H11n9 Tern + inhibitor<br />
**[[4qn5]] - IvNAN H12n5 + sialic acid<br />
**[[4qn5]] - IvNAN H12n5 + sialic acid<br />
-
**[[3san]], [[3ti8]] - IvNAN H12N5 + flu drug<br />
 
-
**[[3san]], [[3ti8]] - IvNAN N5 + flu drug<br />
 
-
**[[4hzw]], [[4hzx]] - IvNAN N3 + flu drug<br />
 
-
**[[4hzz]], [[4i00]] - IvNAN N3 (mutant) + flu drug<br />
 
**[[4h52]], [[4h53]] – IvNAN N2 + inhibitor<br />
**[[4h52]], [[4h53]] – IvNAN N2 + inhibitor<br />
**[[2qwb]] - IvNAN N9 Tern (mutant) + sialic derivative<br />
**[[2qwb]] - IvNAN N9 Tern (mutant) + sialic derivative<br />
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**[[2qwf]], [[2qwg]], [[2qwh]], [[2qwi]], [[2qwj]], [[2qwk]] - IvNAN N9 Tern (mutant) + inhibitor<br />
**[[2qwf]], [[2qwg]], [[2qwh]], [[2qwi]], [[2qwj]], [[2qwk]] - IvNAN N9 Tern (mutant) + inhibitor<br />
**[[1nma]], [[1nmb]], [[1a14]], [[1nca]], [[1ncb]], [[1ncc]], [[1ncd]], [[2aep]], [[2aeq]], [[1nmc]] - IvNAN N9 Tern + antibody – mouse<br />
**[[1nma]], [[1nmb]], [[1a14]], [[1nca]], [[1ncb]], [[1ncc]], [[1ncd]], [[2aep]], [[2aeq]], [[1nmc]] - IvNAN N9 Tern + antibody – mouse<br />
 +
 +
*Binary complexes of Influenza virus neuraminidase with drugs
 +
 +
**[[4b7j]], [[4b7n]], [[4b7q]], [[4b7r]], [[5nzn]], [[6hp0]] - IvNAN H1n1 + drug<br />
 +
**[[5nzf]], [[5nze]], [[5nz4]], [[5nwe]] - IvNAN H1n1 (mutant) + drug<br />
 +
**[[4gzp]], [[4gzt]], [[6br6]], [[6br5]] - IvNAN H3n2 + drug<br />
 +
**[[4qn6]] - IvNAN H3n6 + drug<br />
 +
**[[4wa5]], [[4wa4]] - IvNAN H3n8 + drug<br />
 +
**[[5l15]], [[5l17]], [[5jyy]], [[4mwq]], [[4mwr]], [[4mwu]], [[4mwv]], [[4mww]], [[4mwx]], [[4mwy]], [[4mx0]] - IvNAN H7n9 + drug<br />
 +
**[[4mwq]], [[4mwr]], [[4mwu]], [[4mwv]], [[4mww]], [[4mwx]], [[4mwy]], [[4mx0]] - IvNAN H7n9 + flu drug<br />
 +
**[[4qn7]]- IvNAN H10n7 + drug<br />
 +
**[[3san]], [[3ti8]] - IvNAN H12N5 + flu drug<br />
 +
**[[4hzw]], [[4hzx]] - IvNAN N3 + flu drug<br />
 +
**[[4hzz]], [[4i00]] - IvNAN N3 (mutant) + flu drug<br />
 +
**[[6hg5]] - IvNAN N6 + flu drug<br />
 +
**[[6hfy]] - IvNAN N6 + DANA<br />
 +
**[[6heb]], [[6hcx]] - IvNAN N9 + flu drug<br />
 +
**[[6hg0]] - IvNAN N9 Tern + NANA<br />
*'''Endo-neuraminidase'''
*'''Endo-neuraminidase'''

Revision as of 11:18, 6 November 2019

H5N1 avian influenza virus neuraminidase complex with Tamiflu (PDB entry 2ht7)

Drag the structure with the mouse to rotate

3D structures of Neuraminidase

Updated on 06-November-2019

References

  1. ↑ Matrosovich MN, Matrosovich TY, Gray T, Roberts NA, Klenk HD. Neuraminidase is important for the initiation of influenza virus infection in human airway epithelium. J Virol. 2004 Nov;78(22):12665-7. PMID:15507653 doi:http://dx.doi.org/10.1128/JVI.78.22.12665-12667.2004
  2. ↑ Rutishauser U, Watanabe M, Silver J, Troy FA, Vimr ER. Specific alteration of NCAM-mediated cell adhesion by an endoneuraminidase. J Cell Biol. 1985 Nov;101(5 Pt 1):1842-9. PMID:4055897
  3. ↑ Colli W. Trans-sialidase: a unique enzyme activity discovered in the protozoan Trypanosoma cruzi. FASEB J. 1993 Oct;7(13):1257-64. PMID:8405811
  4. ↑ Paris G, Ratier L, Amaya MF, Nguyen T, Alzari PM, Frasch AC. A sialidase mutant displaying trans-sialidase activity. J Mol Biol. 2005 Jan 28;345(4):923-34. PMID:15588836 doi:10.1016/j.jmb.2004.09.031
  5. ↑ Sylte MJ, Suarez DL. Influenza neuraminidase as a vaccine antigen. Curr Top Microbiol Immunol. 2009;333:227-41. doi: 10.1007/978-3-540-92165-3_12. PMID:19768409 doi:http://dx.doi.org/10.1007/978-3-540-92165-3_12
  6. ↑ Schenkman S, Eichinger D, Pereira ME, Nussenzweig V. Structural and functional properties of Trypanosoma trans-sialidase. Annu Rev Microbiol. 1994;48:499-523. PMID:7826016 doi:http://dx.doi.org/10.1146/annurev.mi.48.100194.002435
  7. ↑ Russell RJ, Haire LF, Stevens DJ, Collins PJ, Lin YP, Blackburn GM, Hay AJ, Gamblin SJ, Skehel JJ. The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design. Nature. 2006 Sep 7;443(7107):45-9. Epub 2006 Aug 16. PMID:16915235 doi:http://dx.doi.org/10.1038/nature05114

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Michal Harel, Alexander Berchansky, Joel L. Sussman, Eran Hodis

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